酶处理异槲皮苷（enzymatically modified isoquercitrin，EMIQ）是以异槲皮苷为底物经酶促糖基化得到的高水溶性黄酮衍生物，其生物利用度显著高于槲皮素及芦丁。大量研究表明EMIQ具有广泛的药理作用，包括抗氧化、抗炎、抗过敏、心血管保护及促进肌肉生长等作用，还能通过激活AMPK信号通路实现对糖脂代谢的精准调控。动物与临床研究均证实其安全可靠，已被日本和美国批准用于食品添加。系统综述了EMIQ的结构特征、理化性质、制备工艺、药理作用及安全性评价，以期EMIQ的深入研究及产业化发展提供坚实的理论依据与实践指导。

Enzymatically modified isoquercitrin (EMIQ) is a highly water-soluble flavonoid derivative produced through enzymatic glycosylation of isoquercitrin. Compared with quercetin and rutin, EMIQ exhibits markedly improved bioavailability. A growing body of research has demonstrated that EMIQ possesses a broad spectrum of pharmacological activities, including antioxidant, anti-inflammatory, anti-allergic, cardiovascular-protective, and muscle-enhancing effects. In addition, EMIQ can precisely regulate glucose and lipid metabolism, primarily through activation of the AMPK signaling pathway. Both animal experiments and clinical studies have confirmed its safety and reliability, and EMIQ has been approved for use as a food additive in Japan and the United States. This article provides a comprehensive review of the structural features, physicochemical properties, preparation methods, pharmacological activities, and safety evaluations of EMIQ, with the aim of offering a solid theoretical foundation and practical guidance for future research and industrial development of this compound.

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