目的 基于CiteSpace知识图谱对傣药肾茶Clerodendranthus spicatus的相关研究文献进行可视化分析，系统梳理近年研究动态，阐述研究热点及未来发展趋势，为肾茶的深入研究与应用提供参考。方法 分别在中国知网（China National Knowledge Infrastructure，CNKI）和Web of Science（WOS）核心集中检索肾茶在中医药领域的中英文文献，检索时间跨度为1995年1月1日—2025年10月30日，将CNKI和WOS检索到的记录分别导入NoteExpress文献管理软件，通过软件自动比对及人工核查，剔除同一数据库内部的重复记录，按纳入与排除标准筛选文献。基于筛选后的文献数据集，利用CiteSpace和Microsoft Excel对发文量、发文作者、研究机构、国家分布、关键词等进行可视化图谱分析。此外，对排名前10位的中英文文献进行高被引文献分析。结果 筛选后共纳入626篇文献，其中包括中文文献274篇，英文文献352篇；发文量总体呈波动式上升趋势。中英文文献发表量最多的作者分别为宋立群和Ismail Zhari，作者合作网络显示团队内部合作较为紧密，不同团队间联系有限；发文量最多的研究机构分别是中国医学科学院药用植物研究所云南分所和Universiti Sains Malaysia，核心机构来自中医药类研究院所与高校。马来西亚成为发文量最多的国家。关键词分析显示中文文献的研究热点主要为药材资源、传统应用、临床研究等方面；英文文献更侧重于化学成分分析、药理作用、数据挖掘、分子机制等方面；高被引文献分析表明，相关研究主要聚焦于化学成分与物质基础、药理作用及机制、制剂工艺和现代方法学创新、综合性研究进展等方面，基本形成“成分-药效-制剂”相互支撑的研究框架。结论 肾茶在中医药领域的研究热度持续升高，其在防治肾病、类风湿关节炎、痛风、骨关节炎、肿瘤等相关疾病的药理机制与临床应用已成为热点。未来可通过整合系统药理学和多组学技术，加强作用机制探索，建立科学的质量控制与临床评价体系，促进肾茶现代化开发和成果产出，为肾茶研究与民族药创新提供参考。

Objective To perform a visualized bibliometric analysis of research on the Dai medicine Clerodendranthus spicatus in the field of traditional Chinese medicine based on the CiteSpace knowledge graph, systematically summarize recent research trends, clarify hotspots and future directions, and provide a reference for further development and application of C. spicatus. Methods Chinese and English literature on C. spicatus in traditional Chinese medicine was retrieved from China National Knowledge Infrastructure (CNKI) and the Web of Science (WOS) Core Collection from 1 January 1995 to 30 October 2025. Records from each database were imported into NoteExpress for automatic and manual de-duplication, and then screened according to predefined inclusion and exclusion criteria. Based on the final dataset, CiteSpace and Microsoft Excel were used to perform visual analyses of publication output, authors, institutions, country distribution and keywords. In addition, the top 10 most-cited Chinese and English articles were subjected to high-cited literature analysis. Results A total of 626 publications were included, comprising 274 Chinese and 352 English articles, with an overall fluctuating upward trend in annual output. The most productive authors were Song Liqun and Ismail Zhari. Co-authorship networks showed relatively close collaboration within research teams but limited cooperation between different teams. The most productive institutions were the Yunnan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, and Universiti Sains Malaysia, with core institutions mainly being traditional Chinese medicine research institutes and universities. Malaysia was the most productive country. Keyword analysis indicated that Chinese studies mainly focused on medicinal resources, traditional uses and clinical research, whereas English literature emphasized phytochemical profiling, pharmacological activities, data mining and molecular mechanisms. High-cited literature analysis revealed that both Chinese and English classic studies chiefly concentrated on chemical constituents and material basis, pharmacological effects and mechanisms, preparation technology and modern methodological innovation, as well as research progress, collectively forming a “constituent-pharmacology-formulation” research framework. Conclusion Research on C. spicatus in the field of traditional Chinese medicine has shown sustained growth, with its pharmacological mechanisms and clinical applications in the prevention and treatment of kidney diseases, rheumatoid arthritis, gout, osteoarthritis, and cancer becoming major research hotspots. Future studies should integrate systems pharmacology and multi-omics technologies, strengthen mechanistic exploration, and establish scientific quality control and clinical evaluation systems, thereby promoting the modernization and innovative development of C. spicatus and providing a reference for research on this herb and other ethnic medicines.

G350;R282.71

国家自然科学基金项目（82374427）；国家自然科学基金项目（82260928）；国家自然科学基金项目（82260925）；云南省重大科技专项计划生物医药专项（202402AA310028）；云南省中医学一流学科创新科研基金项目（ZYXYB202407）；云南省中医药高层次人才中医药学科后备人才培养项目（云财社[2024]103号）；云南省科学技术厅-云南中医药大学应用基础研究联合专项面上项目（202101AZ070001-241）