基孔肯雅热（chikungunya fever，CHIK）是一种由基孔肯雅病毒引起、经伊蚊传播的急性传染病，以发热、关节痛和皮疹为主要临床表现，部分患者可发展为慢性关节炎，目前尚无特效抗病毒药物。基于中医“风邪”理论，系统综述了风药防治该病的作用与机制。CHIK属“湿温”“疫病”范畴，核心病机为风邪夹湿、热、毒，客于肌表经络，其“善行数变”的特点与疾病急性期骤起高热、慢性期游走性关节痛的临床表现高度契合。风药（葛根、防风、羌活、防己等）兼具祛风、胜湿、通络之功，贯穿于CHIK各期治疗。代表方剂如宣痹汤、蠲痹汤能显著改善临床症状。现代研究表明，其活性成分通过直接抑制病毒复制、调控免疫炎症反应等多靶点机制发挥治疗作用。为中医药抗病毒提供了理论依据，彰显了风药在防治新发传染病中的独特价值。

Chikungunya fever (CHIK) is an acute infectious disease caused by chikungunya virus and transmitted by Aedes mosquitoes. Its main clinical manifestations are fever, joint pain and rash, and some patients may develop into chronic arthritis. At present, there are no specific antiviral drugs. Based on the theory of “wind evil” in traditional Chinese medicine, this paper systematically summarizes the role and mechanism of wind medicine in preventing and treating this disease. CHIK belongs to the category of “damp-heat” and “epidemic disease”, and its core pathogenesis is that wind and evil are mixed with dampness, heat and toxin, which are confined to muscle surface meridians. Its characteristics of “good behavior and variable numbers” are highly consistent with the clinical manifestations of sudden high fever in acute stage and wandering joint pain in chronic stage. Wind drugs [such as Gegen (Puerariae Lobatae Radix), Fangfeng (Saposhnikoviae Radix), Qianghuo (Notopterygii Rhizoma et Radix), Fangji (Stephaniae Tetrandrae Radix), etc.] have the functions of expelling wind, eliminating dampness and dredging collaterals, and run through all stages of treatment of CHIK. Representative prescriptions such as Xuanbi Decoction and Juanbi Decoction can significantly improve clinical symptoms. Modern research shows that its active components play a therapeutic role by directly inhibiting virus replication, regulating immune inflammatory response and other multi-target mechanisms. This study provides a theoretical basis for antivirus of traditional Chinese medicine, and highlights the unique value of wind medicine in preventing and treating new infectious diseases.

R285

国家重点研发计划资助项目（2024YFE0214800）；国家自然科学基金资助项目（82404916）；广东省科技计划资助项目（2025B1212030002）；广东省工程技术研究中心（2024A137）；广东省普通高校工程技术研究（开发）中心（2024GCZX010）