目的 利用科学计量学的方法对栀子研究的中英文文献进行可视化分析，探究该领域的研究进展和未来发展趋势。方法 通过Bibliometrix和VOSviewer软件对中国知网、维普、万方、Web of Science、Scopus、PubMed数据库中栀子领域截至2025年的研究文献进行科学计量学分析，从年度发文量、国家、机构、期刊、关键词、主题演化等维度出发，对国内外栀子研究进行可视化分析。结果 共检索到相关中文文献5 049篇、英文文献639篇，开展栀子领域研究的国家以中国为主，研究力量呈现显著的地域与机构集中特征，核心贡献多来自国内一线中医药院校。近年来，栀子研究的热度持续增长，中英文文献均重点关注栀子苷等活性成分的药理机制、提取工艺优化及质量控制体系建设等方面。中文文献更侧重于传统复方的应用与产业化开发，而英文文献则更多聚焦于分子机制层面与国际合作。科学计量分析结果表明，栀子关键活性成分的药理活性、毒性作用、研究方法（网络药理学、代谢组学、分子对接以及响应面法）是目前研究的重点和热点。结论 通过科学计量学方法对栀子中英文文献进行了分析及可视化，确定了栀子药理活性、毒性作用、研究技术与方法中的重点和热点，对栀子及其活性成分的深入研究和未来课题的选择具有一定的参考意义。

Objective This paper uses scientometrics methods to conduct a visual analysis of Chinese and English literature on the Zhizi (Gardeniae Fructus) to explore its research progress and future development trends. Methods Bibliometrix and VOSviewer software were used to conduct a scientometric analysis of research literature in the field of the Gardeniae Fructus in the China National Knowledge Infrastructure (CNKI), VIP, Wanfang, Web of Science, Scopus, PubMed databases up to 2025. From the perspectives of annual publication volume, countries, institutions, journals, keywords, and theme evolution, a visual analysis of the research on Gardeniae Fructus at home and abroad was conducted. Results A total of 5 049 relevant Chinese and 639 English literature were retrieved. The countries that conduct research in the field of Gardeniae Fructus are mainly China. The research forces show a significant regional and institutional concentration feature, and the core contributions are mostly from leading Chinese universities of traditional Chinese medicine. In recent years, the popularity of research on the Gardeniae Fructus has continued to grow, with both Chinese and English literature focusing on the pharmacological mechanisms of active ingredients such as geniposide, extraction process optimization, and quality control system construction. Chinese research focuses more on the application and industrial development of traditional formulas, while English research focuses more on molecular mechanisms and international collaboration. Scientometric analysis indicates that the pharmacological activity and toxicity of key active ingredients in the Gardeniae Fructus, as well as research methods such as network pharmacology, metabolomics, molecular docking, and response surface methodology, are currently the focus and hotspots of research. Conclusion This study analyzed and visualized the Chinese and English literature on the Gardeniae Fructus using scientometric methods, and identified the research priorities and hot topics in the pharmacological activities, toxic effects, and research techniques and methods of Gardeniae Fructus. This has certain reference significance for in-depth research on the Gardeniae Fructus and its active ingredients, as well as for the selection of future research topics.

R284;R285

陕西省重点研发计划项目(2025SF-YBXM-096)