目的 基于CiteSpace与VOSviewer对五加属Eleutherococcus植物的研究现状进行文献计量与可视化分析，并对其未来研究趋势进行预测；通过分析五加属植物的专利布局，评估其技术转化现状与发展趋势，为后续的研发与产业化方向提供决策依据。方法 在中国知网数据库（CNKI）、维普中文科技期刊全文数据库（VIP）、万方数据知识服务平台（Wanfang）、Web of Science（WOS）4个数据库分别以五加属、Eleutherococcus等为关键词进行检索，将检索出的文献导入NoteExpress软件进行筛选并去重，导出数据后用CiteSpace和VOSviewer可视化软件对文献的发文量分布，作者、机构合作网络及关键词聚类和共现网络进行可视化分析。运用Incopat专利数据库的检索功能，针对五加属植物所申请的全球专利趋势、全球地域分布、申请人排名及类型构成等方面进行分析与总结。结果 共纳入中文文献2 081篇，英文文献462篇。五加属近10年中文文献发文量大体呈波动下降后趋于平稳趋势，英文文献呈现波动上升趋势。发文量较多的国家以中国为主，作者合作网络多以团队内部合作为主，团队间合作相对不足。借助Incopat专利数据库共检索到五加属植物相关专利数据18 992件，国内专利有9 942件，占比52.35%，占据全球此方面专利数的一半以上。结论 五加属国内研究正处于波动下降阶段，国外研究正处于上升阶段，研究多以刺五加和无梗五加为主，研究热点趋向于其活性成分、氧化应激、现代药理学及资源保护等方面。五加属植物专利在全球分布差距明显，我国的专利申请量较多，但近年来面临申请活跃度相对降低及创新性不足等问题。

Objective To conduct a bibliometric and visual analysis using CiteSpace and VOSviewer on the current research, status of plants in the genus Eleutherococcus and predict future research trends. Additionally, by analyzing the patent landscape of Eleutherococcus plants, this study aims to evaluate the current status and development trends of its technological transformation, thereby providing a decision-making basis for subsequent research, development, and industrialization. Methods Literature searches were performed in four databases: China National Knowledge Infrastructure (CNKI), Chinese Sci-Tech Journal Full-text Database (VIP), Wanfang Data Knowledge Service Platform (Wanfang), and Web of Science (WOS), using keywords such as “Eleutherococcus” The retrieved literature was imported into NoteExpress software for screening and deduplication. The exported data were then visualized using CiteSpace and VOSviewer to analyze the distribution of the number of published papers, author and institutional collaboration networks, as well as keyword clustering and co-occurrence networks. The search function of the Incopat patent database was utilized to analyze and summarize global patent trends, geographical distribution, applicant rankings, and applicant type composition related to Eleutherococcus plants. Results A total of 2 081 Chinese articles and 462 English articles meeting the criteria were included. Over the past decade, the number of Chinese publications on Eleutherococcus generally showed a fluctuating decline before stabilizing, while English publications exhibited a fluctuating upward trend. China was the leading country in terms of publication volume. Author collaboration networks were primarily based on intra-team cooperation, with relatively insufficient inter-team collaboration. Through the Incopat patent database, 18 992 patent records related to Eleutherococcus plants were retrieved. Among these, 9 942 patents (52.35%) were domestic applications in China, accounting for more than half of the global patents in this field. Conclusion Domestic research on Eleutherococcus in China is currently in a phase of fluctuating decline, while international research is on the rise. Studies predominantly focus on Acanthopanax senticosus and A. sessiliflorus, with research hotspots trending toward active components, oxidative stress, modern pharmacology, and resource conservation. The global distribution of patents related to Eleutherococcus plants shows significant disparities. Although China has a relatively high number of patent applications, it faces challenges such as reduced application activity in recent years and insufficient innovation.

G350;R282

江苏省中医疫病研究中心开放课题(JSYB2024KF28); 江苏省中医流派研究院开放课题(JSZYLP2024040); 无锡市中医药科技发展专项重点项目(ZYZD202404); 无锡市卫生健康委科技计划项目(T202549,M202329); 无锡市名中医工作室(锡中医[2023]2号〈11〉); 无锡市“双百”中青年医疗卫生拔尖人才培养计划(HB2023106)