糖尿病是一种慢性代谢性疾病，受生活方式和饮食结构的影响，患病率逐年上升。肉桂Cinnamomi Cortex是一种广泛应用的天然药物和食物，常用于调味品、香料、农业、医药等领域。肉桂对血糖具有调节作用，为了促进其在医疗和日常生活中更好、更安全的应用，对肉桂调节血糖的作用和机制，以及潜在不良反应进行了综述。发现肉桂降血糖的化学成分包括肉桂多酚、肉桂醛、肉桂多糖、羟基肉桂酸、反式肉桂酸、樟脑、黄酮类化合物等。它作为一种补充剂，可能可以通过调节糖原代谢、糖脂代谢、氧化应激、炎症反应、肠促胰素、消化酶活性等多种途径发挥调节血糖的作用。肉桂是一种相对安全的补充剂，但在较高剂量下仍存在毒性反应，包括肝脏毒性、肾脏毒性、皮肤过敏等。

Diabetes is a chronic metabolic disease, and its prevalence is increasing annually owing to the influence of lifestyle and diet structure. Rougui (Cinnamomi Cortex) is a widely used natural medicine and food commonly used in condiments, spices, agriculture, medicine, and other fields. Cinnamomi Cortex exerts a regulatory effect on blood glucose. To promote its better and safer application in medical practice and daily life, this article reviews the role and mechanism of Cinnamomi Cortex in regulating blood glucose, as well as its potential toxic and side effects. It is found that the chemical components of cinnamon responsible for lowering blood glucose include cinnamon polyphenols, cinnamaldehyde, cinnamon polysaccharides, hydroxycinnamic acid, trans-cinnamic acid, flavonoids, camphor, etc. As a supplement, it may regulate blood glucose through multiple pathways such as regulating glycogen metabolism, glycolipid metabolism, oxidative stress, inflammatory response, incretins, and digestive enzyme activity. Cinnamomi Cortex is a relatively safe supplement, but toxic reactions may still occur at higher doses, including hepatotoxicity, nephrotoxicity, and skin allergies.

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四川省科技计划重点研发项目（2024YFFK0159）；中国博士后科学基金面上项目（2023MD734104）