姜黄素是姜黄Curcumae Longae Rhizoma中的一种多酚类活性单体，具有抗肿瘤、抗炎、抗氧化、代谢调节等药理作用。现有研究表明，姜黄素在肿瘤疾病、炎症性疾病及代谢性疾病等领域表现出广泛的生物学潜力。然而，其在吸收、分布、代谢和排泄等药动学过程中存在水溶性差、生物利用度低等问题，限制了临床应用的进一步推进。针对上述不足，国内外学者采用聚合物纳米粒、聚合物胶束、纳米乳等新剂型技术，以提高姜黄素的溶解度、稳定性、靶向性和生物利用度。通过系统综述姜黄素的“药理-临床研究-药动-剂型”等方面最新进展，检索中国知网、PubMed、Web of Science等数据库中姜黄素药理作用、临床研究、药动学及制剂开发的最新研究进展进行归纳总结，并结合新型递送系统的设计策略讨论其临床转化潜力，为姜黄素的深入研究与应用提供参考。

Curcumin is a polyphenolic active compound in Jianghuang (Curcumae Longae Rhizoma), exhibiting pharmacological effects such as antitumor, anti-inflammatory, antioxidant, and metabolic regulation properties. Existing research indicates that curcumin demonstrates broad biological potential in fields including tumor diseases, inflammatory diseases, and metabolic disorders. However, issues such as poor water solubility and low bioavailability during its pharmacokinetic processes—including absorption, distribution, metabolism, and excretion—have limited further advancement in clinical applications. To address these limitations, researchers worldwide have employed novel delivery technologies such as polymeric nanoparticles, polymeric micelles, and nanoemulsions to enhance curcumin's solubility, stability, targeting efficiency, and bioavailability. This systematic review summarizes the latest advances in curcumin's pharmacology, clinical research, pharmacokinetics, and formulation development by analyzing databases including CNKI, PubMed, and Web of Science. It also discusses the clinical translation potential of novel delivery systems and their design strategies, providing a reference for further research and application of curcumin.

R283

国家自然科学基金资助项目（U1704181）；河南省高等学校重点科研项目（24A360006）；河南省中医药科学研究专项（20-21ZY1010）；第七批全国老中医专家学术经验继承工作及继承人（国中医药人教函[2022]76号）；河南省卫生健康委员会（2023ZY2004）；河南省本科高校青年骨干教师（2023GGJS083）；河南省科技攻关计划（252102310481）