紫菀Asteris Radix et Rhizoma作为经典止咳化痰中药，其应用历史可溯至《神农本草经》。在丝绸之路文明交流背景下，敦煌医学典籍P.2882所载紫菀配伍方剂，体现了东西方医学知识的融合与传播。通过整合本草学考证与现代研究方法，系统解析紫菀的化学成分、药理作用及临床应用。研究表明，紫菀中紫菀酮等三萜类、环肽astins及黄酮类成分是其止咳化痰、抗炎、抗肿瘤作用的药效物质基础；其与款冬花Farfarae Flos、葶苈子（Descurainiae Semen或Lepidii Semen）等配伍形成的经典药对在慢性阻塞性肺疾病、哮喘及肺癌治疗中显示出明确疗效。为紫菀的深入开发提供科学依据，更展现了丝路文明交流在传统药物研究中的重要价值。

Ziwan (Asteris Radix et Rhizoma) is a classic traditional Chinese medicine for relieving cough and resolving phlegm. Its application history can be traced back to Shennong’s Classic of Materia Medica. Under the background of the Silk Road civilization exchange, the compatibility prescription of Asteris Radix et Rhizoma contained in Dunhuang medical classics P.2882 reflects the integration and dissemination of Eastern and Western medical knowledge. Through the integration of herbal textual research and modern research methods, the chemical composition, pharmacological effects and clinical application of Asteris Radix et Rhizoma were systematically analyzed. Studies have shown that triterpenes such as shionone, cyclic peptide astins and flavonoids in Asteris Radix et Rhizoma are the material basis of its antitussive and expectorant, anti-inflammatory and anti-tumor effects. The classical drug pairs formed by its compatibility with Kuandonghua (Farfarae Flos) and Tinglizi (Descurainiae Semen or Lepidii Semen) have shown clear efficacy in the treatment of chronic obstructive pulmonary disease, asthma and lung cancer. It provides a scientific basis for the in-depth development of Asteris Radix et Rhizoma, and shows the important value of Silk Road civilization exchange in traditional medicine research.

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教育部产学合作协同育人项目（2412133147）；甘肃省中医药科研课题（GZKZ-2022-9）；甘肃中医药大学2022年教学研究与改革一般项目（3106010201）；敦煌医学与转化教育部重点实验室开放课题（DHYX24-15）