目的 研究云南藤黄Garcinia yunnanensis枝叶醋酸乙酯部位中联苯类化学成分。方法 基于联苯衍生物的紫外光谱特征吸收，综合采用正相硅胶柱、Sephadex LH-20 凝胶柱和半制备HPLC等方法进行目标分离纯化。依据单体化合物的理化性质与波谱数据，并结合相关文献进行结构鉴定。通过抑制一氧化氮生成实验，评价新化合物的抗炎活性。结果 从云南藤黄醋酸乙酯部位中分离得到8个联苯类成分，分别鉴定为 (R)-5-(4-羟基苯基)-2-(2-羟基丙基)-2,3-二氢苯并呋喃-7-醇（1）、garcibiphenyl C（2）、cylindrobiphenyl B（3）、multibiphenyl C（4）、doitungbiphenyls B（5）、multiflorabiphenyl B（6）、和厚朴酚（7）和厚朴酚（8）。结论 化合物1为新化合物，命名为藤黄联苯A（yunnabiphenyl A）；化合物2～8均为首次从该植物中分离得到。化合物1显示一定的抗炎活性，其半数抑制浓度（median inhibition concentration，IC₅₀）为21.5μmol/L。

Objective To investigate the biphenyl compounds in the ethyl acetate-soluble fraction of the twigs of Garcinia yunnanensis. Methods Based on the UV spectral characteristics absorption of biphenyl derivatives, targeted separation and purification were performed using various chromatography techniques, including silica gel column chromatography, Sephadex LH-20 gel column and semi-preparative HPLC. The structures of the isolated compounds were elucidated by means of physicochemical properties and spectral data of the monomer compounds, in combination with relevant literature. The anti-inflammatory activity of the new compound was evaluated by measuring its inhibition effect of nitric oxide (NO) production. Results Eight bipheny derivatives were obtained from the ethyl acetate fraction of G. yunnanensis, elucidated as (R)-5-(4-hydroxyphenyl)-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-7-ol (1 ), garcibiphenyl C (2 ), cylindrobiphenyl B (3 ), multibiphenyl C (4 ), doitungbiphenyls B (5 ), multiflorabiphenyl B (6 ), honokiol (7 ), and magnolol (8 ). Conclusion Compound 1 is a new compound named yunnabiphenyl A, while compounds 2 —8 were reported from this plant for the first time. Compound 1 showed moderate anti-inflammatory activity, with a median inhibition concentration (IC₅₀) value of 21.5 μmol/L.

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国家自然科学基金资助项目（82160660）；江西省自然科学基金资助项目（20212ACB206006）；江西中医药大学“1050”工程人才项目（5142001004）与创新团队（CXTD22015）