目的 探析2000—2024年全球中医药研究学者在延胡索研究领域的跨地域多维合作情况并梳理研究热点、前沿动态及研究主题的地域分布，为延胡索后续的研究提供参考依据。方法 收集源于中国知网（CNKI）、万方数据（Wanfang）、维普中文科技期刊数据库（VIP）、Web of Science数据库（WOS）及PubMed数据库等与延胡索相关的文献。采用文献计量软件Coocation（COOC20.0）与VOSviewer1.6.20软件相结合的方式，从发文量、核心发文作者、高产发文机构、关键词共现以及突现词检测等多个维度进行可视化分析，构建延胡索热点前沿知识图谱。结果 21世纪以来，国内外有关延胡索研究的发文量呈逐渐上升趋势，中国为延胡索研究的核心国家。国内各大高校院所为延胡索中文文献研究的主要机构，合作范围为各中医药研究单位及相关企业，延胡索研究热点主要集中在其成分、药效物质基础等方面。延胡索英文文献主要发文机构为我国科研院所，研究热点主要集中在延胡索中生物碱类有效成分分离、结构解析、延胡索质量分析方法建立及生物碱活性机制评价等方面。结论 延胡索研究已经进入多元化、纵深发展阶段，未来有望将人工智能、多组学联合等前沿技术应用于延胡索靶点、作用机制、复方用药规律等方面的研究。

Objective To explore the cross-regional and multi-dimensional cooperation of global traditional Chinese medicine (TCM) researchers in the field of research on the TCM Corydalis yanhusuo from 2000 to 2024, and to sort out the research hotspots, frontier trends and regional distribution of research topics, so as to provide reference for the subsequent research on C. yanhusuo. Methods Literature on C. yanhusuo was retrieved from databases such as China National Knowledge Infrastructure (CNKI), Wanfang, VIP, Web of Science (WOS), and PubMed. The bibliometric software Coocation (COOC20.0) combined with VOSviewer 1.6.20 was used to conduct a visual analysis from multiple dimensions, including the number of publications, core authors, prolific institutions, keyword co-occurrence, and new word discovery, to construct a knowledge map of research hotspots and frontiers for C. yanhusuo. Results Since the 21st century, the number of papers published on C. yanhusuo research at home and abroad has gradually increased, and China is the core country for C. yanhusuo research. Major universities and research institutes in China are the main institutions for C. yanhusuo research, and the scope of cooperation exists in various TCM research units and related enterprises. English publications on C. yanhusuo are mostly contributed by Chinese research institutions, with hotspots concentrating on isolation and structural elucidation of alkaloid active components, establishment of quality assessment methods, and evaluation of alkaloid activity mechanisms. Conclusion Research on C. yanhusuo has entered a stage of diversified and in-depth development. In the future, it is expected that cutting-edge technologies such as artificial intelligence and multi-omics will be applied to the research on C. yanhusuo targets, mechanisms of action, and compound medication rules.

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国家自然科学基金（82304727）；国家中医药管理局全国老药工传承工作室（[2024]255号）；陕西省重点研发计划项目（2022SF-183）；陕西省中医药管理局项目（TZKN-CXRC-12）；“秦药”研发重点实验室（2021-QYPT-001）；陕西省中医药管理局中医药全省性专款专项项目（2021-QYZL-01）；陕西省卫生健康创新团队-秦药质量控制与创新产品研发创新团队