皮肤光老化是因长期紫外线辐射引起的一种皮肤损伤，临床表现主要包括皱纹形成、色素沉着、皮肤弹性减弱，甚至可进展为癌前病变。在治疗皮肤光老化方面，传统药物制剂常存在透皮性能差、靶向能力弱及药物滞留时间短等问题。近年来，以酚酸类、多糖、皂苷等活性成分为基础构建的智能响应型水凝胶，为皮肤光老化的修复提供了新型治疗策略。此类水凝胶不仅能负载具备抗氧化、抗炎及促进胶原合成等功能活性成分，还可对光老化皮肤的微环境产生自主响应，从而实现药物的精准递送。通过系统综述智能响应型水凝胶的响应机制及其在皮肤光老化治疗中的研究进展，为开发高效、精准的外用制剂并推动其在该领域的应用提供新思路与理论参考。

Skin photoaging is a type of skin damage caused by long-term exposure to ultraviolet radiation, clinically characterized mainly by wrinkle formation, pigmentation, reduced skin elasticity, and potential progression to precancerous lesions. In the treatment of skin photoaging, conventional pharmaceutical formulations often face challenges such as poor transdermal performance, weak targeting capability, and short drug retention time. In recent years, intelligent responsive hydrogels constructed based on various active ingredients such as phenolic acids, polysaccharides, and saponins have provided novel therapeutic strategies for the repair of skin photoaging. These hydrogels can not only load functional components with activities such as antioxidant, anti-inflammatory, and collagen synthesis promotion but also autonomously respond to the microenvironment of photoaged skin, thereby achieving precise drug delivery. This paper systematically reviews the response mechanisms of intelligent responsive hydrogels and their research progress in the treatment of skin photoaging, aiming to provide new insights and theoretical references for the development of efficient and accurate topical formulations and to promote their application in this field.

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国家自然科学基金资助项目（82173982）；广东省自然科学基金资助项目（2022A1515011382）