目的 研究海洋真菌Talaromyces sp.13-z-02的次级代谢产物及其抗炎活性。方法 采用硅胶和ODS柱色谱以及半制备液相色谱对发酵产物进行分离和纯化，并利用质谱和核磁共振等方法鉴定化合物的结构。基于斑马鱼模型对分离得到的化合物进行抗炎活性评价。结果 从Talaromyces sp.13-z-02菌株发酵液中分离鉴定了1个新的色满类化合物以及11个已知化合物，分别为8-羟基-6-甲氧基-7-甲基异色满（1）、芽孢杆菌素B（2）、大孢酮D（3）、芽孢杆菌素F（4）、1-epi-芽孢杆菌素F（5）、大孢酮E与1-epi-大孢酮E（6）、芽孢杆菌素A（7）、异克劳辛（8)、Sch 725680（9）、阿库烯C（10）、6-乙基-2-羟基-4-甲氧基-3-甲基苯甲醛（11）、6-乙基-2,4-二羟基-3-甲苯甲醛基（12）。化合物1和12在20 μmol/L时显著降低免疫细胞迁移率（P＜0.01）。结论 化合物1为新的色满类化合物，命名为篮异色满；化合物1和12具有抗炎活性。

Objective To investigate the secondary metabolites produced by marine-derived fungi Talaromyces sp. 13-z-02 and their anti-inflammatory activities were studied. Methods The isolation and purification of compounds were performed using silica gel and ODS column chromatography, semi-preparative HPLC. And their structures were elucidated by MS and NMR analyses. The isolated compounds were evaluated for their anti-inflammatory activity in zebrafish. Results One new isochromane and eleven known compounds were isolated and identified as 8-hydroxy-6-methoxy-7-methylisochromane (1) from the fermentation broth of this strain, bacillisporin B (2), macrosporusone D (3), bacillisporin F (4), 1-epi-bacillisporin F (5), macrosporusone E and 1-epi-macrosporusone E (6), bacillisporin A (7), xenoclauxin (8), Sch 725680 (9), aculene C (10), 6-ethyl-2-hydroxy-4-methoxy-3-methylbenzaldehyde (11), 6-ethyl-2,4-dihydroxy-3-methylbenzaldehyde (12). Compounds 1 and 12 significantly reduced the migration of immune cells with the same concentration of 20 μmol/L and exhibited anti-inflammatory activity. Conclusion Compound 1 is a new isochromane, designated as talaroslisochromane. Compounds 1 and 12 showed anti-inflammatory activity.

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国家自然科学基金青年项目（82204276）;广西自然科学基金项目（2025GXNSFAA069557）;广西高等学校千名中青年骨干教师培育计划;自治区级大学生创新创业训练计划（S202310608216）