地黄苷D是药食同源中药地黄Rehmannia glutinosa的指标性成分。地黄苷D属于天然环烯醚萜苷类化合物，具有滋阴补血、凉血止血、镇痛、抗抑郁、抗骨质疏松等药理作用，因此对其研究日益深入。综述了近年来地黄苷D的研究进展，详细总结了地黄苷D测定方法的优化与新技术应用，及在不同剂型中的含量测定；归纳了不同产地、不同炮制方法及地黄不同组织含量变化规律；并重点阐述了地黄苷D在内分泌与心血管系统、神经系统等方面的药理学作用。此外，对地黄苷D在研究中存在的相关问题进行讨论，为地黄苷D的深入研发和临床应用，及地黄的质量鉴定和资源综合利用提供科学依据。

Rehmannioside D is an indicator component of Dihuang (Rehmanniae Radix), a traditional Chinese medicine that shares the same origin in both medicine and food. Rehmannioside D, a natural iridoid glycoside, exhibits a broad spectrum of pharmacological activities, including nourishing yin and blood, cooling blood and stopping bleeding, providing analgesia, acting as an antidepressant, and preventing osteoporosis, thereby meriting intensified investigation. This paper systematically reviews the recent advances in rehmannioside D research, detailing the optimization of determination methods and the application of new technologies for rehmannioside D, as well as the content determination in different dosage forms. The principles of content variation in different producing areas, processing methods, and tissues of Rehmanniae Radix are summarized. Furthermore, it focuses on elucidating the pharmacological effects of rehmannioside D in the endocrine and cardiovascular systems, nervous system, and other aspects. In addition, this paper critically discusses the existing challenges in its research. The aim is to provide a scientific basis for the further development and clinical application of rehmannioside D, as well as the quality identification and comprehensive utilization of Rehmanniae Radix.

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国家自然科学基金资助项目(32300600);中国博士后科学基金资助项目(2023M730995);河南省高等学校重点科研项目(25A360031);河南农业大学高层次人才专项支持基金项目(30501461)