目的 从文献计量学和全球专利的角度对钩藤的研究动态与焦点进行全面分析，为未来钩藤的临床应用和深入研究提供前瞻参考。方法 以钩藤为关键词检索中国知网（CNKI）、万方（Wanfang）、维普（VIP）、Web of Science（WOS）4个数据库，将文献导入NoteExpress文献管理软件中进行查重和筛选。利用Excel、Origin、CiteSpace、VOSviewer等软件，从发文趋势与国家分布、发文机构、发文期刊、发文作者、关键词等维度对国内外的钩藤研究现状与发展趋势进行可视化分析。通过Incopat专利数据库从专利申请趋势、全球地域分布、专利申请人及专利技术领域等方面检索并分析钩藤相关全球专利申请情况。结果 共检索到符合标准的中文文献1 713篇，英文文献594篇。发文国家以中国为主，国际上对钩藤的关注度也显著提升。钩藤领域的核心团队已初步形成，但机构间合作有待加强。近年来钩藤领域中英文文献研究热点存在交叉现象，均聚焦于钩藤的药理活性成分、作用机制，中文文献聚焦天麻钩藤饮及钩藤用于高血压的治疗及调控机制与活性成分；英文文献侧重于植物化学、抗炎抗氧化作用及神经疾病的潜在疗效。基于Incopat专利数据库检索经初步筛选得到8 048件专利，实施同族合并操作后，保留专利6 251项，其中国内专利数量为5 461，占比87.36%，占据主导地位。结论 钩藤领域研究呈现出不断拓展与深化的态势，整体上正从传统中医药实践转向多学科协同创新与分子水平机制深入解析的发展路径。中国虽然在钩藤专利的国际申请中占据主导地位，却存在关键弊端：专利失效规模较大、转化实施程度有限且市场拓展乏力。

Objective To comprehensively analyze the research trends and focuses of Gouteng (Uncariae Ramulus Cum Uncis) from bibliometric and global patent perspectives, providing forward-looking references for its future clinical application and in-depth research. Methods Literature was retrieved from four databases: China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and Web of Science (WOS) with Uncariae Ramulus Cum Uncis as the keyword. Retrieved publications were imported into NoteExpress for deduplication and screening. Software including Excel, Origin, CiteSpace, and VOSviewer were used to visually analyze the current research status and development trends of Uncariae Ramulus Cum Uncis in domestic and international publications, covering publication trends, national distribution, publication institutions, journal of publication, authors, and keywords. The Incopat patent database was searched to analyze global patent applications related to Uncariae Ramulus Cum Uncis, including trends in patent applications, geographical distribution, applicants, and technology fields. Results A total of 1 713 Chinese publications and 594 English publications met the inclusion criteria. China was the primary contributor to publications, with international attention increasing gradually in recent years. Core research teams have emerged in this field, but collaboration among institutions requires strengthening. In recent years, there has been an overlap in the research hotspots of Chinese and English literature in the field of Uncariae Ramulus Cum Uncis, both focusing on the pharmacological components and action mechanisms of Uncariae Ramulus Cum Uncis. Chinese studies specifically emphasize Tianma Gouteng Decoction and its use in hypertension treatment, identifying bioactive compounds and elucidating regulatory mechanisms. English publications focus on phytochemistry, anti-inflammation, antioxidation, and the potential efficacy in neurological diseases. Based on a search of the Incopat patent database, 8 048 patents were initially screened. After merging patent families, 6 251 patents were retained, among which 5 461 were domestic patents, accounting for 87.36% and occupying a dominant position. Conclusion Research in the field of Uncariae Ramulus Cum Uncis shows a trend of continuous expansion and deepening. Overall, it is shifting from traditional Chinese medicine practice to a development path featuring multi-disciplinary collaborative innovation and in-depth analysis of molecular-level mechanisms. Although China dominates international patent applications related to Uncariae Ramulus Cum Uncis, there are key drawbacks: A large number of patents have expired, the degree of transformation and implementation is limited, and market expansion is weak.

G350;R282.71

江苏省中医疫病研究中心开放课题(JSYB2024KF28);江苏省中医流派研究院开放课题(JSZYLP2024040,JSZYLP2024042);无锡市卫生健康委科技计划项目(M202329,T202549,M202552);无锡市中医药科技发展专项重点项目(ZYZD202404);无锡市名中医工作室(锡中医[2023]2号〈11〉)