溃疡性结肠炎（ulcerative colitis，UC）是一种结直肠黏膜呈弥漫性、连续性病变的慢性非特异性炎症性疾病。研究显示，氨基酸及其代谢产物具有抗炎、抗氧化、修复肠道屏障及调节免疫反应等生物活性，进而靶向干预UC核心病理特征。中医药可有效抑制UC的疾病进展，改善复杂临床症状，减轻化学药相关不良反应及并发症。基于此，从中医药调控氨基酸代谢重编程治疗UC这一创新性视角出发，系统阐述中药复方制剂及其活性成分在调节氨基酸代谢重编程中的药理作用机制，为中医药治疗UC提供新的思路与理论支持，推动其现代化应用与发展。

Ulcerative colitis (UC) is a chronic, nonspecific inflammatory disease characterized by diffuse, continuous lesions of the colorectal mucosa. Accumulating evidence indicates that amino acids and their metabolites exhibit biological activities such as anti-inflammation, anti-oxidation, repair of intestinal barrier and regulation of immune response. These effects enable targeted intervention in the core pathological characteristics of UC. Traditional Chinese medicine (TCM) can effectively inhibit the disease progression of UC. It also alleviates complex clinical symptoms and reduces the adverse reactions and complications associated with Western therapies. Based on this, this article adopts a novel perspective of TCM regulating amino acid metabolic reprogramming to treat UC. This review systematically dissect the pharmacological mechanisms by which herbal formulas and their bioactive constituents modulate amino-acid metabolic reprogramming. It aims to furnish new therapeutic concepts and a theoretical framework for the use of TCM in managing UC, thereby accelerating its modernization and clinical translation.

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国家自然科学基金资助项目（82360896）；甘肃省杰出青年基金资助项目（24JRRA556）；敦煌医学与转化教育部重点实验室开放课题（DHYX24-02）