骨骼肌作为人体主要能量代谢器官之一，其脂质代谢异常与多种代谢性疾病密切相关。近年来，中药在调节骨骼肌脂代谢方面的研究逐渐增多。中药活性成分及复方在改善骨骼肌脂代谢紊乱中具有良好的潜在应用价值。相关研究表明，中药通过调节脂肪酸氧化、脂肪生成及脂滴代谢等途径促进骨骼肌脂质稳态的恢复，进而改善机体能量代谢和代谢性疾病的病理状态。通过系统综述中药调控骨骼肌脂代谢的分子机制，为代谢疾病的防治提供理论依据和药物研发方向，推动中医药在代谢性疾病治疗领域的应用与发展。

Skeletal muscle is one of the major organs for energy metabolism in the human body, and abnormalities in its lipid metabolism are closely linked to various metabolic diseases. Recent research has increasingly focused on the role of traditional Chinese medicine (TCM) in regulating skeletal muscle lipid metabolism. Both active TCM components and TCM compound prescriptions have shown promising potential in ameliorating skeletal muscle lipid metabolic disorders. Studies indicate that these TCM interventions restore skeletal muscle lipid homeostasis by modulating fatty acid oxidation, lipogenesis, and lipid droplet metabolism, which in turn improves systemic energy metabolism and ameliorates the pathologies of metabolic diseases. This review systematically summarizes the molecular mechanisms of TCM in regulating skeletal muscle lipid metabolism, providing a theoretical basis and drug development directions for the prevention and treatment of metabolic diseases, and promoting the application and development of TCM in the field of metabolic disease treatment.

R285

现代中药制造业创新中心项目（TC230A075）