IgA血管炎性肾炎（IgA vasculitis nephritis，IgAVN）作为儿童及青少年常见的继发性肾小球疾病，因发病率上升、病情易反复等问题，严重影响患者的生存质量，探索安全有效的治疗策略，已成为当前医学领域的重要研究方向。中医药治疗IgAVN具有多靶点调节优势，其中雷公藤及其活性成分在改善肾损伤中疗效确切。基于国内外相关研究，系统阐述雷公藤改善IgAVN肾损伤的作用机制，包括抑制炎症反应、调节免疫失衡、诱导异常细胞凋亡、改善凝血状态等，并深入探讨其相关信号通路的调控网络及作用靶点，为雷公藤在肾损伤治疗中的临床应用提供理论依据与研究参考。

IgA vasculitis nephritis (IgAVN), as a common secondary glomerular disease in children and adolescents, seriously affects patients’ quality of life due to the increasing incidence, recurrent episodes, and other issues. Exploring safe and effective therapeutic strategies has become an important research direction in the current medical field. Traditional Chinese medicine possesses a multi-target regulatory advantage in the treatment of IgAVN, among which Leigongteng (Tripterygium wilfordii) and its active components exert definite curative effects in improving renal injury. Based on research progress at home and abroad, this paper systematically elaborates on the mechanisms of T. wilfordii in alleviating IgAVN-related renal injury, including inhibiting the inflammatory response, regulating immune imbalance, inducing abnormal cell apoptosis, and improving coagulation status. It further explores the regulatory networks and target of its related signaling pathways, so as to provide theoretical bases and research reference for the clinical application of T. wilfordii in the treatment of IgAVN-related renal injury.

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国家自然科学基金资助项目（82305311）；国家自然科学基金资助项目（82305310）；中国博士后科学基金面上项目（2023M741094）；河南省自然科学基金资助项目（242102311265）；河南省中医药科学研究专项课题（2023ZXZX1132）；河南省卫生健康委员会国家中医药传承创新中心联合共建科研专项（2024ZXZX1062）；河南省医学科技攻关计划联合共建项目（LHGJ20240675）