目的 对红花八角Illicium dunnianum干燥地上部分茎叶中木脂素类成分进行研究。方法 综合运用AB-8、硅胶、ODS、Sephadex LH-20等柱色谱和制备、半制备液相等多种色谱方法进行分离纯化，并根据化合物的理化性质和核磁共振波谱数据进行准确的结构鉴定。结果 从红花八角茎叶70%乙醇提取物中分离鉴定9个木脂素类化合物，分别为 (7S,8R)-4,5',9,9'-四羟基-3-甲氧基-4',7-环氧-8,3'-新木脂素-9-O-(4-乙酰基)-α-L-吡喃鼠李糖基(1→2)-β-D-吡喃木糖苷（1）、(7R^*,8R^*)-4,7,9,9'-四羟基-3,5,3'-三甲氧基-8-O-4'-新木脂素（2）、(7R^*,8R^*)-7,9,9'-三羟基-3,3',5'-三甲氧基-4-O-β-D-葡萄糖基-8-O-4'-新木脂素（3）、rourinoside（4）、(7S^*,8R^*)-5-甲氧基二氢去氢二愈创木基醇-4-O-β-D-吡喃葡萄糖苷（5）、(7S^*,8R^*)-urolignoside（6）、(7S^*,8R^*)-二氢去氢二愈创木基醇-9-O-β-D-吡喃葡萄糖苷（7）、(7S^*,8R^*)-二氢去氢二愈创木基醇-9'-O-β-D-吡喃葡萄糖苷（8）、异落叶松脂素-9'-O-β-D-吡喃葡萄糖苷（9）。结论 化合物1为新的木脂素，命名为八角木脂素Q（illiciumlignan Q），化合物2、4、5、8与9为首次从八角属中分离化合物，3、6与7为首次从红花八角中分离化合物。

Objective To study the lignans from the dried stems and leaves of Illicium dunnianum. Methods Separation and purification were carried out by comprehensively applying various chromatographic methods such as AB-8, silica gel, ODS, Sephadex LH-20 column chromatographys, and preparative, semi-preparative liquid chromatographys. Moreover, the structures were identified based on the physicochemical properties and nuclear magnetic resonance spectroscopy data of the compounds. Results Atotal of nine lignans were isolated and identified from the 70% ethanol extract of the stems and leaves of I. dunnianum, including (7S,8R)-4,5',9,9'-tetrahydroxy-3-methoxy-4',7-epoxy-8,3'-neoligan-9-O-(4-acetyl)-α-l-rhamnopyranosyl(1→2)-β-D-xylopyranoside (1), (7R^*,8R^*)-4,7,9,9'-tetrahydroxy-3,5,3'-trimethoxy-8-O-4'-neolignan (2), (7R^*,8R^*)-7,9,9'-trihydroxy-3,3',5'-trimethoxy-4-O-β-D-glucosyl-8-O-4'-neolignan (3), rourinoside (4), (7S^*,8R^*)-5-methoxydihydrodehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside (5), (7S^*,8R^*)-urolignoside (6), (7S^*,8R^*)-dihydro-dehydrodiconiferyl alcohol-9-O-β-D-glucopyranoside (7), (7S^*,8R^*)-dihydrodehydrodiconiferyl alcohol-9'-O-β-D-glucopyranoside (8), isolariciresinol-9'-O-β-D-glucopyranoside (9), respectively. Conclusion Compound 1 was a new lignan (illiciumlignan Q), 2, 4, 5, 8, and 9 were isolated from Illicium for the first time, and 3, 6, and 7 were isolated from I. dunnianum for the first time.

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2024广东省医学科学基金项目（A2024561）；2025广东省中医药局科研项目（20251215）；江苏省卫生健康职业技术教育研究项目：药物制剂公共实训基地产业化实践探索与教育研究（WJ202404）