动物类中药肽类（animal-derived traditional Chinese medicine，TCM）物质活性优势显著，但由于动物源性中药研究程序缓慢且昂贵、材料基础不规范、活性成分不明确等原因，尚未得到深入研究。回顾了用于动物类中药生物活性肽的研究现状，不同提取、纯化和鉴定技术的最新进展，并介绍其潜在健康益处。利用酶水解、溶剂萃取和微生物发酵等方式提取，然后通过膜过滤系统、色谱法等方法结合适当的方法进行鉴定，可以高效率的产生肽并且得到更高的生物活性。此外，还介绍了动物类中药发挥的抗炎、抗氧化、抗菌、抗高血压和抗肿瘤活性等多功能健康益处及其构效关系。动物源性中药多肽的低开发和资源浪费，以及大多数动物源性中药肽的药理活性报告不足，使其具有良好的研究前景。虽然在保健品领域已经取得了突破，但如果落实上述困惑和当前需求，将获得更多的临床产品发展潜力。

The peptide substances in animal-derived traditional Chinese medicine (TCM) have significant advantages in biological activity. However, due to the slow and expensive research process of animal-derived TCM, non-standard material basis, unclear active ingredients and other reasons, in-depth research has not yet been conducted. In this article, we review the current research status of bioactive peptides from animal-derived TCM, the latest progress in different extraction, purification and identification technologies, and introduce their potential health benefits. Extraction using methods such as enzymatic hydrolysis, solvent extraction and microbial fermentation, followed by identification through membrane filtration systems, chromatography, electrophoresis combined with appropriate methods, can efficiently produce peptides with higher biological activity. In addition, the multifunctional health benefits of animal-derived TCM, such as anti-inflammatory, antioxidant, antibacterial, antihypertensive and anti-tumor activities, as well as their structure-activity relationships, are also introduced. The low development and resource waste of peptides from animal-derived TCM, along with the insufficient reports on the pharmacological activities of most animal-derived TCM peptides, give them promising research prospects. Although breakthroughs have been made in health products, more potential for the development of clinical products will be achieved if the above-mentioned challenges and current needs are addressed.

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药用陆生脊椎动物资源调查项目(DWZY21001)