卵巢衰老是女性生殖功能衰退的标志性过程，卵巢功能减退引起不孕逐渐成为当代女性面临的生育困境。线粒体-内质网结构偶联（mitochondria-associated endoplasmic reticulum membranes，MAMs）是线粒体外膜与内质网膜间的紧密接触区域，对细胞稳态的维持至关重要。MAMs功能障碍介导的钙稳态失衡、内质网应激失控、线粒体质量控制异常及氧化应激损伤等与卵巢衰老密切相关，近年来成为研究卵巢衰老机制的新靶点。中药在改善卵巢功能、延缓卵巢衰老具有多靶点协同调控特性。通过系统归纳整理了钙稳态失衡、内质网应激失控、线粒体质量控制异常、氧化应激损伤等MAMs功能障碍介导卵巢衰老的研究现状，及中药恢复MAMs功能延缓卵巢衰老的潜在作用机制，明确现阶段研究进展与不足，为卵巢衰老的防治提供新的科学依据和治疗策略，对延长女性生育窗口期，提高生育率，改善人口结构老龄化现状具有积极意义。

Ovarian aging is a symbolic process of female reproductive function decline. Infertility caused by ovarian dysfunction has gradually become a reproductive dilemma faced by contemporary women. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are tight contact areas between the outer mitochondrial membrane and the endoplasmic reticulum membrane, which are essential for the maintenance of cell homeostasis. MAMs dysfunction-mediated calcium homeostasis imbalance, endoplasmic reticulum stress out of control, mitochondrial quality control abnormalities and oxidative stress damage are closely related to ovarian aging. In recent years, it has become a new target for studying the mechanism of ovarian aging. Traditional Chinese medicine (TCM) has multi-target synergistic regulation characteristics in improving ovarian function and delaying ovarian aging. This paper systematically summarizes the research status of MAMs dysfunction mediated ovarian aging, such as calcium homeostasis imbalance, endoplasmic reticulum stress out of control, abnormal mitochondrial quality control, oxidative stress injury, and the potential mechanism of TCM to restore MAMs function to delay ovarian aging, and clarifies the current research progress and shortcomings, to provide new scientific basis and treatment strategies for prevention and treatment of ovarian aging, which is of positive significance for prolonging the window period of female fertility, improving fertility and improving the aging status of population structure.

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