全球抗菌药物耐药性危机持续加剧，被世界卫生组织列为十大公共卫生威胁之一。传统抗菌药物疗效逐渐下降，急需开发新型抗菌制剂。碳点作为一种新兴碳纳米材料，凭借其优异的纳米特性，在抗菌领域展现出广阔前景。近年来，基于绿色合成理念，研究人员创新性地采用中药材作为碳源，通过水热法等制备出中药衍生碳点（traditional Chinese medicine-derived carbon dots，TCM-CDs）。该类碳点不仅继承中药本身的活性成分，具备多靶点抗菌、不易诱导耐药性的特点，还表现出独特的纳米生物学效应，为应对耐药菌感染提供了新策略。通过系统综述TCM-CDs的制备方法、结构表征与功能特性，重点探讨其在伤口感染治疗中的应用潜力与机制，并分析其临床转化与安全性评价面临的挑战，为抗感染纳米药物的研发提供参考。

The global crisis of antimicrobial resistance (AMR) continues to intensify and has been listed as one of the top ten public health threats by the World Health Organization. The efficacy of traditional antibiotics is gradually declining, and there is an urgent need to develop new antibacterial agents. Carbon dots, as an emerging carbon nanomaterial, have shown broad prospects in the field of antibacterial field due to their excellent nanoscale properties. In recent years, based on the concept of green synthesis, researchers have innovatively used traditional Chinese medicine as a carbon source to prepare traditional Chinese medicine derived carbon dots (TCM-CDs) through hydrothermal methods. This type of carbon dot not only inherits the active ingredients of traditional Chinese medicine itself, but also has the characteristics of multi-target antibacterial and not easily inducing drug resistance. It also exhibits unique nanobiological effects, providing a new strategy for dealing with drug-resistant bacterial infections. This article provides a systematic review of the preparation methods, structural characterization, and functional properties of TCM-CDs, with a focus on exploring their potential and mechanisms for application in wound infection treatment. It also analyzes the challenges faced in their clinical translation and safety evaluation, with the aim of providing reference for the development of anti-infective nanomedicines.

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大学生创新创业训练计划项目(GDMU2023374,GDMU2023287);广东医科大学本科生创新创业教育基地项目(JDXM2024104);广东省教育厅“创新强校工程”科研项目(2024KQNCX108)