目的 采用文献计量学方法对中药超分子的研究现状及热点进行可视化分析，为后续研究提供借鉴与参考。方法 通过中国知网（CNKI）和Web of Science（WOS）检索2000—2024年与中药超分子相关的文献；利用CiteSpace软件对作者、国家、机构和关键词等进行可视化分析。结果 共纳入499篇文献，其中中文文献166篇，英文文献333篇；中药超分子相关文献年发文量总体呈上升趋势；这些文献来自多个国家，发文量和中心性最大的国家均是中国；中英文发文量最多的均是中国作者，分别是湖南中医药大学的贺福元教授和北京中医药大学的王鹏龙教授；湖南中医药大学和北京中医药大学是该领域的重要研究机构；关键词分析显示“药物递送”“纳米体系”和“天然小分子”是热门研究领域；“超分子”“自组装”和“印迹模板”等主题代表着新兴的研究方向；中文文献主要聚焦在从自组装超分子的角度阐释中药配伍的科学内涵；英文文献则更多的研究中药超分子的形成机制，并对其结构进行解析。结论 中药超分子为中医药现代化研究提供了新视角。然而其发展仍面临着诸多挑战，如中药超分子体内自组装研究理论体系尚不完善、缺乏动态跟踪中药超分子自组装过程的检测技术等。借助文献计量学方法，能够客观、系统地呈现该领域的发展现状和最新研究热点，从而为创新性研究提供思路，推动中药超分子研究向更深入、更系统的方向发展。

Objective To visually analyze the research status and hotspots of traditional Chinese medicine supramolecules by bibliometrics method, provide a reference for the follow-up research. Methods China Knowledge Network (CNKI) and Web of Science (WOS) were used to search the literature related to supramolecules of traditional Chinese medicine from 2000 to 2024. The authors, countries, institutions, co-citations, and keywords were visually analyzed by CiteSpace software. Results A total of 499 articles were included, including 166 in Chinese and 333 in English. The data show that the number of articles published in supramolecular-related literature on traditional Chinese medicine was generally on the rise. This literature comes from many countries, and the country with the largest volume and centrality was China. The authors who publish the most articles in both Chinese and English were from China, respectively Professor He Fuyuan from Hunan University of Chinese Medicine and Professor Wang Penglong from Beijing University of Chinese Medicine. Hunan University of Chinese Medicine and Beijing University of Chinese Medicine were famous research institutions in this field. The keywords analysis shows that “drug delivery”, “nano-system” and “natural small molecules” were hot research fields. Topics such as “supramolecular”, “self-assembly” and “imprinted template” represent emerging research directions. Chinese mainly focuses on explaining the scientific connotation of the compatibility of traditional Chinese medicine from the perspective of self-assembled supramolecules, whereas English literatures paid more attention to investigating the formation mechanism of traditional Chinese medicine supramolecules and analyzing their structures. Conclusion Supramolecular traditional Chinese medicine provides a new perspective for the research on the modernization of traditional Chinese medicine. However, its development still faces many challenges, such as the incomplete theoretical system for the in vivo self-assembly research of traditional Chinese medicine supramolecules and the lack of detection techniques for dynamically tracking the self-assembly process of traditional Chinese medicine supramolecules. By means of bibliometric methods, the current development status and the latest research hotspots in this field can be objectively and systematically presented, thereby providing ideas for innovative research and promoting the supramolecular research of traditional Chinese medicine to develop in a deeper and more systematic direction.

G350;R284

国家自然科学基金项目(82204656);博士后科学基金特别资助(2024T170534);山东省中医药科技项目(M20241725);山东中医药大学青年创新团队支持计划(22202105)