目的 为系统性地把握巴马汀（palmatine）领域的研究现状和热点方向，采用文献计量学方法，对国内外巴马汀研究趋势进行可视化分析。方法 以巴马汀为关键词，检索中国知网（CNKI）和Web of Science（WOS）2个数据库，将文献导入NoteExpress文献管理软件中进行查重和筛选。使用Excel、CiteSpace、VOSviewer、WPS等软件，从发文趋势与国家分布、发文机构、发文作者、关键词等层面，对国内外巴马汀研究现状进行可视化分析。结果 共检索到符合要求的中文文献3 742篇，英文文献712篇。中国在巴马汀研究领域占主导地位，近年来国际关注度也逐年提高，整体研究呈现出持续发展态势。国内主要以团队独立研究为主，且多由高校主导，缺乏药企的深度参与，国家合作网络密度较低。巴马汀领域的中英文文献均重点关注巴马汀的药理作用，包括心血管疾病、抗炎、抗肿瘤、代谢调控等领域，而中文文献同时关注了巴马汀的提取分离与含量测定等。结论 巴马汀研究呈现“基础强、转化弱”的典型天然产物特征，未来需通过多靶点协同作用、剂型临床适配性优化及国际合作网络强化，突破当前发展瓶颈。

Objective In order to systematically deconstruct the current research status and hot directions in the field of palmatine, this study adopts bibliometric methods to visualise and analyse the domestic and international literature on palmatine. Methods With palmatine as the keyword, two databases, China Knowledge Network (CNKI) and Web of Science (WOS), were searched, and the literature was imported into NoteExpress literature management software for checking and screening. Using Excel, CiteSpace, VOSviewer, WPS and other software, the current status of domestic and international research on palmatine was visualised and analysed at the levels of issuing trends and national distribution, issuing institutions, issuing authors and keywords. Results A total of 3 742 Chinese and 712 English documents were retrieved that met the requirements. China dominates the research field of palmatine, and the international attention has been increasing year by year in recent years, and the overall research has shown continuous development. Domestic research is mainly based on team-independent research and is mostly dominated by universities, lacking the deep participation of pharmaceutical companies, and the density of national cooperation networks is low. Both Chinese and English literature in the field of palmatine focus on the pharmacological effects of palmatine, including cardiovascular disease, anti-inflammation, anti-tumor, metabolic regulation and other areas, while Chinese literature focuses on extraction, separation and content determination of palmatine at the same time. Conclusion Palmatine research presents the typical natural product characteristics of ‘strong foundation, weak transformation’, and in the future, it is necessary to break through the current development bottleneck through the synergistic effect of multi-targets, the optimisation of the clinical suitability of the dosage form, and the strengthening of the international cooperation networks.

G350;R284

国家自然科学基金资助项目(82174065);云南省科技厅社会发展专项-重点研发计划项目(202303AC100025);云南省朱兆云院士工作站(202405AF140128);云南省教育厅科学研究基金项目(2024Y379);云南省中西医结合慢病防治重点实验室开放基金资助项目(YPKLG2024-016);云南省傣医药与彝医药重点实验室资助项目(2024SS24074)