目的 基于CiteSpace和VOSviewer文献计量学方法，分析赤芍的研究现状，预测其未来研究热点与发展趋势，为开发新型中药提供有价值的参考和指导。方法 分别检索中国知网数据库（CNKI）、万方数据库及Web of Science（WOS）核心合集数据库中赤芍研究相关文献，利用NoteExpress软件删除重复及不合格文献，并统一关键词格式。运用CiteSpace、VOSviewer和Excel软件，分别对中英文文献的发文量、发文期刊、发文作者、发文机构及关键词等进行可视化分析。结果 共纳入有效文献932篇，其中中文文献848篇，英文文献84篇。中文文献发文量呈现波动趋势，而英文文献则呈上升趋势，刊载赤芍研究文献最多的中英文期刊分别为《中草药》（17篇）和Journal of Ethnopharmacology（13篇）；发文量最高的作者分别为毛德文（14篇）和Cai Shaoqing（5篇）。在相关研究机构中，中英文发文量最多的机构分别为北京中医药大学（46篇）和天津中医药大学（6篇）。中英文关键词共现与聚类分析结果表明，当前研究热点主要集中于赤芍的化学成分、提取工艺、药理作用、临床应用及作用机制。结论 赤芍研究目前仍处于上升发展阶段。未来研究应重点关注作用机制解析、化学成分深入研究及分子对接技术应用等方面。

Objective To analyze the current research status and predict future hotspots and development trends of Chishao (Paeoniae Radix Rubra) using bibliometric methods with CiteSpace and VOSviewer, providing valuable references and guidance for the development of new types of traditional Chinese medicine. Methods Literatures related to Paeoniae Radix Rubra were retrieved from CNKI, Wanfang, and Web of Science (WOS) Core Collection databases. Duplicate and irrelevant publications were removed using NoteExpress, followed by keywords standardization. Bibliometric indicators, including publication volume, journals, authors, institutions and keywords, were visualized and analyzed via CiteSpace, VOSviewer and Excel for both Chinese and English literatures. Results A total of 932 eligible literatures were included (848 Chinese, 84 English). Chinese publications exhibited a fluctuating trend, while English publications steadily increased. The top journals with the highest number of published literatures on Paeoniae Radix Rubra were Chinese Traditional and Herbal Drugs (17 Chinese articles) and Journal of Ethnopharmacology (13 English articles). The most prolific authors were Dewen Mao (14 articles) and Shaoqing Cai (five articles). Among the relevant research institutions, the ones with the largest number of published articles in both Chinese and English were Beijing University of Chinese Medicine (46 articles) and Tianjin University of Traditional Chinese Medicine (six articles), respectively. Co-occurrence and clustering analyses of Chinese and English keywords revealed five core research hotspots, which primarily focused on chemical constituents, extraction methods, pharmacological effects, clinical applications, and mechanisms of action. Conclusion Research on Paeoniae Radix Rubra remains a upward developmental phase. Future studies should prioritize analysis of mechanism of action, in-depth research on chemical composition, and applications of molecular docking technology.

G350；R282.71

国家自然科学基金项目（82473925）；黑龙江省重点研发计划（GA21C006）