[关键词]
[摘要]
中药及炮制品来源的细胞外囊泡（EVs）是一种来源于植物类中草药特定部位的细胞所分泌的纳米级膜囊泡，富含中草药活性成分，具有独特的生物活性、良好的生物相容性和靶向递送潜力，是中药现代化研究的重要方向。系统综述了中药及炮制品囊泡的研究进展，重点总结其提取技术、表征方法以及炮制工艺对囊泡性质的影响，并探讨其在疾病治疗中的应用潜力。通过整合传统炮制理论与现代纳米技术，中药炮制囊泡为中药炮制理论的现代化诠释和创新应用提供了新视角，同时为其临床转化提供理论依据和技术参考。
[Key word]
[Abstract]
Extracellular vesicles (EVs) derived from Chinese herbal medicines and their processed products are nanoscale membrane vesicles secreted by cells from specific parts of medicinal plants. These EVs are rich in bioactive components of herbs, exhibit unique biological activities, excellent biocompatibility, and potential for targeted delivery, making them a significant focus in the modernization of traditional Chinese medicine (TCM) research. This article systematically reviews the research progress on EVs from Chinese herbal medicines and their processed products, with an emphasis on extraction techniques, characterization methods, and the influence of processing technologies on vesicle properties. It also explores their application potential in disease treatment. By integrating traditional processing theories with modern nanotechnology, EVs from processed herbal medicines offer a novel perspective for the modern interpretation and innovative application of TCM processing theories, while providing a theoretical and technical foundation for clinical translation.
[中图分类号]
R286.2
[基金项目]
国家自然科学基金资助项目（81960713）；国家自然科学基金资助项目（82160750）；国家自然科学基金资助项目（82574743）；国家自然科学基金资助项目（82560778）；甘肃省教育厅产业支撑计划项目（2021CYZC21）；甘肃省科技计划（创新基地与人才计划〉基础研究创新群体项目（21JR7RA569）；2024年甘肃省人才重点项目（中药炮制技术传承创新团队建设与示范推广）（2024RCXM77）；高校产业支撑项目（2024CYZC41）；2024年甘肃省联合科研基金（红黄芪炮制增效机理及物质基础研究）（24JRRA882）
