肌肉骨骼疾病（musculoskeletal diseases，MSDs）是源于运动系统损伤或慢性疼痛的炎性及退行性病变，其机制尚未明晰，现有疗法存在疗效有限、不良反应显著且成本高等缺陷，亟待开发新型安全治疗策略。中草药囊泡（Chinese herbal medicine derived extracellular vesicles-like particles，CHM-EVLP）在完整保留原生药材药理活性的同时，可突破传统制剂稳定性差、生物利用度低等瓶颈，兼具高效递送、组织靶向和良好生物相容性优势，为MSDs治疗提供了新思路。通过系统解析CHM-EVLP的生物合成机制、组分特性及其分离纯化与保存工艺，并多维度阐述其表征体系。重点评述其在MSDs治疗中的创新成果，深入分析其作为新型递药系统的功能优势与开发潜力，为CHM-EVLP的药理机制研究和临床转化提供科学依据。

Musculoskeletal diseases (MSDs) are inflammatory and degenerative diseases arising from motor system injury or chronic pain. Their underlying mechanisms remain unclear, and existing treatments suffer from limited efficacy, significant side effects and high cost. It is urgent to develop new safe treatment strategies. Chinese herbal medicine derived extracellular vesicles-like particles (CHM-EVLP) can not only retain the pharmacological activity of original medicinal materials, but also break through the bottleneck of poor stability and low bioavailability of traditional preparations. CHM-EVLP have the advantages of high efficiency delivery, tissue targeting and good biocompatibility, which provides a new idea for the treatment of MSDs. In this paper, the biosynthetic mechanism, component characteristics, isolation, purification and preservation process of CHM-EVLP were systematically analyzed, and their characterization system was described in multiple dimensions. The innovative achievements in MSDs treatment were reviewed, and the functional advantages and development potential of CHM-EVLP as a new drug delivery system were analyzed in depth, thereby providing a scientific basis for future pharmacological research and clinical translation. of CHM-EVLP.

R285

国家自然科学基金面上项目（82174119）；广东省普通高校重点领域专项（2022ZDZX2016）