目的 从文献计量学的角度对中医药在肝纤维化领域的研究现状与热点进行全面分析，为肝纤维化深入研究提供理论指导。方法 以“肝纤维化”“中药”为主题词或关键词在中国知网、万方、维普、中国生物医学文献数据库、Web of Science 5个数据库检索相关文献，使用CiteSpace、VOSviewer等软件，从发文趋势与国家合作、发文机构、发文作者、期刊、被引文献及关键词等维度出发，对国内外中医药在肝纤维化领域研究进行可视化分析。结果 共检索到符合要求的中文文献3 438篇，英文文献3 174篇。肝纤维化研究呈现出持续发展态势，发文国家以中国为主，肝纤维化核心团队已经初步形成，中、英文发文最多的机构分别是广西中医药大学和上海中医药大学，英文发文最多的期刊是Journal of Ethnopharmacology。肝纤维化领域的中文与英文文献均重点关注了中药在肝纤维化病理生理机制的研究，中文文献重点关注炎症、铁死亡及细胞凋亡，而英文文献重点关注氧化应激、肠道菌群、胰岛素抵抗及自噬。结论 中药在肝纤维化领域的研究目前仍较受关注，研究热点主要集中在炎症、肠道菌群、细胞凋亡及自噬等方面，分子对接和网络药理学验证中药靶点可能是新兴趋势。未来应结合分子生物学、人工智能等前沿技术，深入探索中药复方的作用机制，为肝纤维化的精准防治提供参考依据。

Objective To comprehensively analyze the current research status and hotspots of traditional Chinese medicine (TCM) in the field of liver fibrosis from the perspective of bibliometrics, and provide theoretical guidance for future in-depth research on liver fibrosis. Methods Using “liver fibrosis” and “TCM” as the main theme words or keywords, relevant literature was retrieved from five databases: CNKI, Wanfang, VIP, China Biology Medicine disc, and Web of Science. Software such as CiteSpace and VOSviewer were employed to conduct a visual analysis of the research on TCM in the field of liver fibrosis from multiple dimensions, including publication trends, international cooperation, publishing institutions, authors, journals, cited literature, and keywords. Results A total of 3 438 Chinese articles and 3 174 English articles that met the criteria were retrieved. The research on liver fibrosis shows a continuous development trend, with China being the main publishing country. A core research team in the field of liver fibrosis has been preliminarily formed. The institutions with the most publications in Chinese and English literature are Guangxi University of Chinese Medicine and Shanghai University of Traditional Chinese Medicine, respectively. The journal with the most English publications is Journal of Ethnopharmacology. Both Chinese and English literature in the field of liver fibrosis focus on the pathophysiological mechanisms of TCM in liver fibrosis. Chinese literature mainly focuses on inflammation, ferroptosis, and apoptosis, while English literature focuses on oxidative stress, gut microbiota, insulin resistance, and autophagy. Conclusion Research on TCM in the field of liver fibrosis remains highly relevant, with current hotspots mainly concentrated in inflammation, gut microbiota, apoptosis, and autophagy. Molecular docking and network pharmacology for validating TCM targets may represent emerging trends. Future research should incorporate advanced technologies, including molecular biology and artificial intelligence, to elucidate the mechanisms of TCM formulations, thereby offering evidence-based strategies for the precise management of liver fibrosis.

G350；R285

陕西省卫生健康委新药研发与精准用药科研创新平台（2023PT-10）；空军军医大学临床医学与药学创新研究中心项目（LHJJ2024-YX03）；基于人工智能的用药风险防范关键技术创新团队（2023-CX-TD-76）