[关键词]
[摘要]
目的 将真空脉动干燥(pulsation vacuum drying,PVD)技术应用于六味地黄浓缩丸(Liuwei Dihuang Concentrated Pills,LDCP)的干燥,并通过Box-Behnken设计-响应面法(Box-Behnken design-response surface methodology,BBD-RSM)试验设计优化其工艺。方法 以莫诺苷含量、马钱苷含量、丹皮酚含量及平均干燥速率为综合评价指标,探讨干燥温度(50、60、70、80、90 ℃)、真空保持时间(3、6、9、12、15 min)、常压保持时间(2、4、8、12、16 min)对LDCP干燥特性及品质的影响,采用BBD-RSM优化LDCP的PVD工艺参数。结果 干燥温度、真空保持时间、常压保持时间均对LDCP的干燥特性及品质有显著影响。PVD最佳工艺参数为干燥温度62 ℃、真空保持时间5 min、常压保持时间7 min。结论 研究结果可为PVD技术在LDCP干燥工业生产中的应用提供借鉴。
[Key word]
[Abstract]
Objective This study applied pulsation vacuum drying (PVD) technology to the drying process of Liuwei Dihuang Concentrated Pills (LDCP, 六味地黄浓缩丸), the process was optimized through Box-Behnken design-response surface methodology (BBD-RSM) experimental design. Methods Using a composite evaluation index incorporating morroniside content, loganin content, paeonol content, and average drying rate, investigating the effect of drying temperature (50, 60, 70, 80, 90 ℃), vacuum holding time (3, 6, 9, 12, 15 min), and atmosphere pressure holding time (2, 4, 8, 12, 16 min) on the drying characteristics and quality of LDCP, and through the BBD-RSM, the PVD process parameters for LDCP were optimized. Results The drying temperature, vacuum holding time and atmospheric pressure holding time all have significant effects on the drying characteristics and quality of LDCP. The optimum process parameters for PVD are drying temperature 62 ℃, vacuum holding time 5 min, and atmospheric pressure holding time 7 min. Conclusion The research results can provide reference for the application of PVD technology in the industrial production of LDCP drying.
[中图分类号]
R283.6
[基金项目]
国家自然科学基金资助项目(82460774);国家自然科学基金资助项目(81760716);江西省主要学科学术和技术带头人青年人才培养项目(20243BCE51110);江西中医药大学重点学科建设经费资助项目(2023jzzdxk017)