干燥综合征是一种以淋巴细胞增殖及进行性外分泌腺体损伤为特征的自身免疫病，可出现多系统、多脏器受累。目前，关于中西医结合治疗的时机及具体方案尚无可遵循的临床诊疗指南。指南针对最终纳入的临床问题按照“人群（P）、干预（I）、对照（C）、结局（O）”原则检索证据。采用推荐意见分级的评估、制订及评价（grading of recommendations assessment，development and evaluation，GRADE）方法对证据进行分级和质量评价。基于证据等级，考虑疗效、安全性、经济性、患者可接受程度综合权衡后作出推荐强度，采用GRADE网格计票法进行计票，最终形成推荐意见。

Sjögren’s syndrome (SS) is an autoimmune disease characterized by lymphocyte proliferation and progressive exocrine gland damage. Currently, there are no clinical diagnosis and treatment guidelines to follow regarding the timing and specific treatment plans for integrated traditional Chinese and Western medicine treatment. In this guideline, evidence was retrieved for the clinically included issues in accordance with the principles of “population (P), intervention (I), control (C), and outcome (O)”. The grading of recommendations assessment, development and evaluation (GRADE) method was used to grade the evidence and evaluate its quality. Based on the evidence level, the strength of the recommendations was determined after comprehensively weighing the curative effect, safety, economy, and patient acceptability. The GRADE grid voting method was employed for voting, and finally, the recommended opinions were formulated.

R4;R24;R287

国家中医药管理局项目“开展重大疑难疾病中西医结合诊疗方案的研究（干燥综合征中西医结合诊疗指南）”（2023382）；国家中医药管理局项目“滋阴解毒中药治疗干燥综合征的疗效和作用机制”（GZY-KJS-2024-05）；天津市南开区示范试点项目“风湿病（RA、SS、痛风）中医证候规律研究及专家共识制定”（20240204011）；中国民族医药学会科研项目（2020MZ319-350601）；重大疑难疾病中西医临床协作项目-01直达资金-2024年中医药事业传承与发展（第二批）；全国名老中医药专家传承工作室（975022）；中医药传承与创新“百千万”人才工程（岐黄工程）（中医药人民教育函[2018]12号）；国家中医药管理局中医药重点学科能力提升项目—中医痹病学（2018ZDXK001）