随着环境与社会因素的改变，患神志疾病的人数逐年增加。现代医学多运用抗精神病药物治疗，但长期服用易出现失眠、头晕、恶心、自主神经紊乱等不良反应，并且容易产生对药物的耐药性。百合Lilii Bulbus作为治疗神志疾病的常见药材，其最早记载于《神农本草经》，主要用于治疗阴虚燥咳、虚劳惊悸、失眠多梦等疾病。对百合及其有效化学成分在治疗失眠症、抑郁症、焦虑症以及围绝经期综合征等神志疾病的研究进行综述。百合主要通过调节单胺类神经递质、改善肠道菌群、调控下丘脑-垂体-肾上腺轴、缓解炎症及氧化应激等机制，发挥镇静安神的功效，在临床治疗失眠症、抑郁症、焦虑症等神志疾病，具有潜在的研究价值。

With changes in environmental and social factors, the number of people suffering from psychiatric disorders has been increasing year by year. Modern medicine utilizes antipsychotic drugs for treatment, however, long-term use of antipsychotic drugs can cause various side effects, such as insomnia, dizziness, nausea, autonomic disorders, and other adverse reactions, as well as make the patient resistant to the drugs. As a common medicinal herb for the treatment of psychosomatic diseases, Lilii Bulbus was first recorded in Shennong’ Classic of Materia Medica, and is mainly used for the treatment of yin deficiency and dry cough, palpitations due to deficiency labor, insomnia and excessive dreaming. In this paper, we review the research progress of Lilii Bulbus and its effective chemical components in the treatment of insomnia, depression, anxiety and perimenopausal syndrome and other psychosomatic disorders. By regulating monoamine neurotransmitters, improving intestinal flora, regulating the hypothalamic-pituitary-adrenal axis, and alleviating inflammation and oxidative stress, Lilii Bulbus exerts sedative and tranquilizing effects, which is potentially valuable in the clinical treatment of insomnia, depression, anxiety and other psychiatric disorders.

R285

国家自然科学基金资助项目（82360896）；甘肃省自然科学基金资助项目（24JRRA556）；西北营养与环境相关疾病中医药防控协同创新中心开放基金课题（ZYXT-24-06）