多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种常见的生殖内分泌疾病，且临床异质性高。PCOS的病因尚不清楚，但与遗传、代谢、内分泌和环境因素有密切联系。迄今为止，还没有治疗PCOS的特异性药物，PCOS治疗策略仅是针对某些症状。槲皮素具有抗炎、抗氧化、降低血糖和胆固醇及改善内皮功能等药理活性。研究发现，槲皮素能够通过其生物特性改善PCOS临床症状，如改善肥胖、调节性激素水平及缓解多囊卵巢形态等。然而，其确切机制尚未完全阐明。鉴于此，以PCOS的多种病理途径为切入点，探讨槲皮素的作用机制，为临床应用和药物开发提供参考。

Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disease characterized by marked clinical heterogeneity. While the etiology of PCOS remains incompletely understood, it is closely associated with genetic, metabolic, endocrine and environmental factors. To date, no disease-modifying agents specifically targeting PCOS have been established, with current therapeutic strategies focusing solely on symptom management. Quercetin demonstrates multifaceted pharmacological properties including anti-inflammatory, antioxidant, hypoglycemic, and hypocholesterolemic effects, alongside endothelial function improvement. Research has shown that quercetin ameliorates clinical manifestations of PCOS, such as obesity, dysregulated sex hormone profiles, and polycystic ovarian morphology, through its bioactive properties. Nevertheless, the precise mechanistic underpinnings remain incompletely elucidated. Given this, focusing on the diverse pathological pathways implicated in PCOS, this review explores quercetin's mechanisms of action to provide insights for clinical translation and pharmaceutical development.

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黑龙江省卵巢疾病临床医学研究中心（LC2020R009）；国中医药科技中药便函[2023]24号；黑龙江省中医药学会2022—2024年度青年人才托举工程项目（2022-QNRC1-02）