随着人口老龄化的加剧，与衰老相关的疾病发病率逐渐升高。菟丝子Cuscuta Semen不仅是补益类中药的代表性药材，也是抗衰老方剂中出现频次较高的中药之一。大量研究发现，菟丝子及其活性成分具有延缓多个靶器官衰老和治疗衰老相关疾病的作用。通过总结菟丝子不同提取组分及活性成分的抗衰老药效特征，并进一步从衰老相关的基因组不稳定性、细胞衰老、慢性炎症、线粒体功能障碍、干细胞耗竭及自噬功能障碍等生物学机制，分类梳理菟丝子活性成分延缓衰老的潜在作用机制，为菟丝子在抗衰老领域的临床应用提供参考。

With the aging of the population, the incidence of aging-related diseases is progressively increasing. Tusizi (Cuscutae Semen), is not only a representative herb in the category of tonic herbs, but also one of the most frequently used herbs in anti-aging formulas. Numerous studies have found that Cuscutae Semen and its active ingredients have the effect of delaying the aging of multiple target organs and treating age-related diseases. By summarizing the anti-aging pharmacological characteristics of different extracts and active components of Cuscutae Semen, and further categorizing and organizing the potential mechanisms of action of its active components in delaying aging based on biological mechanisms such as age-related genomic instability, cellular senescence, chronic inflammation, mitochondrial dysfunction, stem cell depletion, and autophagy dysfunction, this review provides a reference for the clinical application of Cuscutae Semen in the field of anti-aging.

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国家重点研发计划项目（2023YFC3504302）