目的 探讨六神丸口服治疗肝经郁热型带状疱疹的临床效果。方法 选取江西省皮肤病专科医院2022年10月—2024年10月门诊肝经郁热型带状疱疹患者100例，采用随机数字表法分组，治疗组和对照组每组各50例，对照组口服阿昔洛韦片及外用阿昔洛韦乳膏，治疗组在对照组基础上口服六神丸。比较两组临床疗效、中医证候积分、皮损评分、视觉模拟评分（visual analogue scale，VAS）、带状疱疹简明疼痛评估量表（zoster brief pain inventory，ZBPI）评分、匹兹堡睡眠量表（Pittsburgh sleep quality index，PSQI）评分、炎性因子、T淋巴细胞亚群、不良反应发生率、带状疱疹后神经痛（postherpetic neuralgia，PHN）发生率。结果 治疗后，治疗组总有效率（96.00%）和显效率（78.00%）明显优于对照组（分别为84.00%和52.00%）（P＜0.05）。治疗后，两组中医证候积分、皮损评分、VAS、ZBPI评分、PSQI评分均较治疗前降低，且治疗组显著低于对照组（P＜0.01）。治疗后，两组的炎性因子［白细胞介素-1β（interleukin-1β，IL-1β）、IL-6、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）］均较治疗前降低，且治疗组显著低于对照组（P＜0.05）。治疗后，两组的T细胞CD4⁺、CD4⁺/CD8⁺较治疗前升高，且治疗组显著高于对照组（P＜0.05），两组CD8⁺均较治疗前降低，且治疗组显著低于对照组（P＜0.05）。治疗后，皮疹愈合后1个月及3个月，治疗组的PHN发生率均明显低于对照组（P＜0.05）；两组均未发生不良反应。结论 六神丸能快速消除带状疱疹皮损、强效止痛、改善睡眠、降低炎性因子水平、调节免疫，降低PHN发病率，显著提高疗效。

Objective To investigate the clinical efficacy of Liushen Pills in the treatment of herpes zoster with liver channel stagnation-heat type. Methods A total of 100 outpatients with herpes zoster of liver channel stagnation-heat type were selected from Jiangxi Provincial Dermatology Hospital from October 2022 to October 2024. They were randomly divided into two groups using a random number table: the treatment group and the control group, each with 50 patients. The control group was treated with oral acyclovir tablets, along with topical acyclovir cream. The treatment group received Liushen Pills orally in addition to the control group’s treatment. The clinical efficacy, traditional Chinese medicine (TCM) syndrome scores, skin lesion scores, visual analog scale (VAS), zoster brief pain inventory (ZBPI), pittsburgh sleep quality index (PSQI), inflammatory factors, T lymphocyte subsets, incidence of adverse reactions, and incidence of postherpetic neuralgia (PHN) were compared between the two groups. Results After treatment, the total effective rate (96.00%) and the markedly effective rate (78.00%) in the treatment group were significantly better than those in the control group (84.00% and 52.00%, respectively) (P < 0.05). After treatment, the TCM syndrome scores, skin lesion scores, VAS, ZBPI, and PSQI scores in both groups decreased compared to before treatment, and the treatment group was significantly lower than the control group (P < 0.01). The levels of inflammatory factors [interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α)] in both groups decreased after treatment, and the treatment group was significantly lower than the control group (P < 0.05). The levels of CD4⁺ T cells and CD4⁺/CD8⁺ ratio increased in both groups after treatment, and the treatment group was significantly higher than the control group (P < 0.05). The CD8+ T cell levels decreased in both groups after treatment, and the treatment group was significantly lower than the control group (P < 0.05). One month and three months after the skin lesions healed, the incidence of PHN in the treatment group was significantly lower than that in the control group (P < 0.05). No adverse reactions occurred in either group. Conclusion Liushen Pills can rapidly eliminate herpes zoster skin lesions, provide strong pain relief, improve sleep, reduce inflammatory factor levels, regulate immunity, and lower the incidence of PHN, and significantly improve treatment efficacy.

R285.64

全国中医药工作示范单位（国中医药办医政发[2017]10号，洪卫中医字[2017]12号）；江西省中医临床重点专科-中西医结合皮肤科（赣卫中医字2018 20号，赣中医药字[2016]1号文）；江西省中西医临床协作试点建设单位（赣中医药综合字[2021]9号）