高尿酸血症（hyperuricemia，HUA）为人体内尿酸代谢紊乱、血尿酸水平持续高于正常值的病理现象。近年来，肠道微生态成为各种代谢性疾病的研究热点。中医药及民族医药多途径、多靶点的治疗优势可以调节肠菌代谢，缓解尿酸升高情况。其主要途径为修复肠屏障，抑制机体低度炎症反应；减少尿酸生成酶分泌；增加尿酸排泄转运蛋白表达。通过文献检索及归纳总结，系统综述以肠道微生态为靶点的中医药及民族医药治疗HUA的机制，以期为肠道功能菌及代谢物的开发和中医药及民族医药治疗HUA提供思路和参考。

Hyperuricemia (HUA) is a pathological condition of uric acid metabolism disorder in the human body, and the blood uric acid level is continuously higher than the normal value. Recently, intestinal microecology has become a research hotspot in various metabolic diseases. The therapeutic advantages of multi-pathway and multiple targets of traditional Chinese medicine and ethnic medicine can regulate the metabolism of intestinal bacteria and alleviate the increase of uric acid. The main way is to repair the intestinal barrier, inhibit the low-degree inflammation, reduce the secretion of uric acid producing enzymes, and increase the expression of uric acid excretion transporter. Through literature retrieval and induction summary, this article systematically reviews the mechanism of traditional Chinese medicine and ethnic medicine treatment of HUA targeting intestinal microecology, in order to provide ideas and references for the development of intestinal functional bacteria and metabolites, and traditional Chinese medicine and ethnic medicine treatment of HUA.

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中央引导地方科技发展资金资助项目（202307AC110004）；云南省中西医结合慢病防治重点实验室开放课题基金（YPKLG2024-026）；云南中医药大学横向课题（2024HX023）