慢性肾脏病（chronic kidney disease，CKD），因其病因及发病机制复杂，目前临床上的治疗手段有限，而大黄作为治疗CKD最常用中药之一，已广泛用于CKD的防治中且效果颇佳。通过检索大黄及其活性成分、复方制剂治疗CKD的相关文献，从临床试验及动物实验两方面系统梳理，并对其涉及的作用机制和相关通路进行归纳总结，以期为CKD的治疗及大黄活性成分的开发提供思路和参考。

Chronic kidney disease (CKD), because of its complex etiology and pathogenesis, there are limited clinical treatments available, but Dahuang (Rhei Radix et Rhizoma), as one of the most commonly used traditional Chinese medicines in the treatment of CKD, has been widely used in the prevention and treatment of CKD and has been shown to be effective. This study searched the literature on Rhei Radix et Rhizoma, its active ingredients and compound preparations for the treatment of CKD, systematically sorted them out from both clinical trials and animal experiments, and summarized their mechanisms of action and related pathways, with a view to providing ideas and references for the treatment of CKD and the development of Rhei Radix et Rhizoma active ingredients.

R284.1

国家自然科学基金资助项目（82160938）；国家中医药管理局第七批全国老中医药专家学术经验继承工作项目（国中医药人教函[2022]76号）；云南省科技厅基础研究计划项目（202101AZ070001-286，202301AZ070001-030）；云南省教育厅科学研究基金项目（2024Y408，2025Y0644）