一贯煎出自清代名医魏之琇的《续名医类案》，由北沙参Glehniae Radix、麦冬Ophiopogonis Radix、当归Angelicae Sinensis Radix、枸杞子Lycii Fructus、地黄Rehmanniae Radix、川楝子Toosendan Fructus 6味药组成。一贯煎组方精妙，是临床滋阴疏肝的首选方剂，广泛用于消化系统及内分泌系统的相关疾病。为深入探索一贯煎的现代研究进展，推动经典名方的研发应用，系统梳理了一贯煎的历史沿革、方义内涵、质量控制、药理作用及近10年的临床应用研究进展，总结了一贯煎在临床上的用药规律，并对一贯煎开发应用所面临的挑战进行深入讨论，为经典名方一贯煎的现代研究提供科学依据。

Yiguanjian (一贯煎) is derived from the Supplement to Classified Case Records of Famous Physicians by Wei Zhixiu, a renowned physician in the Qing Dynasty. It is composed of six medicinal ingredients: Beishashen (Glehniae Radix), Maidong (Ophiopogonis Radix), Danggui (Angelicae Sinensis Radix), Gouqizi (Lycii Fructus), Dihuang (Rehmanniae Radix), and Chuanlianzi (Toosendan Fructus). As the preferred prescription for nourishing yin and soothing the liver in clinic and is widely utilized for diseases related to the digestive and endocrine systems. To further explore the modern research progress of Yiguanjian and promote the development and application of this classical prescription, this paper systematically reviews its historical evolution, formula connotation, quality control, pharmacological effects, and clinical research advances over the past ten years. Furthermore, it summarizes the medication principles of Yiguanjian in clinic and discusses the challenges faced in its development and application, offering a scientific basis for modern research on this classical prescription.

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国家自然科学基金青年科学基金项目（82104659）