目的 对近41年来中药发酵领域的文献展开深入分析与研究，旨在探寻该领域的研究热点及发展趋势，为后续相关研究提供参考依据。方法 在中国知网（CNKI）和Web of Science（WOS）数据库中检索与中药发酵相关的中英文文献，并使用Citespace软件对文献数量和机构、作者合作网络，以及关键词共现、时区聚类、突现进行可视化分析。结果 最终纳入符合要求的中文文献894篇，英文文献185篇。中药发酵研究的中英文文献年发文量呈波动上升趋势，参与该领域研究的国家以中国为主。研究机构主要集中于中国的中医药大学，中英文文献发文量居榜首的机构均为北京中医药大学。中英文文献发文量最多的作者分别是任玉珍和Ma Jin Yeul。中文文献高频关键词为发酵、中药等，英文文献高频关键词为肠道菌群、抗氧化、中药等。中英文关键词聚类、突现显示研究热点集中于发酵机制、菌种、药材、工艺优化及应用。结论 中文文献多集中于中药发酵的工艺、菌种、发酵药材以及应用，英文文献侧重于发酵机制、药理作用、药物合成和提纯，对肠道菌群、代谢、益生菌、生物活性成分的深入研究是未来中药发酵的重点发展趋势。

Objective This study conducts a comprehensive analysis of literature in the field of traditional Chinese medicine (TCM) fermentation over the past 41 years to identify research hotspots and development trends, providing reference for future studies. Methods Chinese and English literatures related to TCM fermentation were retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases. Visualization analysis of publication quantity, institutional and author collaboration networks, keyword co-occurrence, time-zone clustering, and burst detection was performed using CiteSpace software. Results A total of 894 Chinese and 185 English publications meeting the requirements were finally included. The annual publication volume of Chinese and English literatures on TCM fermentation shows a fluctuating upward trend. The countries involved in the research of this field include China and South Korea, with China being the main contributor. The research institutions are mainly concentrated in Chinese universities of TCM. Beijing University of Chinese Medicine ranks first in the number of publications in both Chinese and English literatures. The authors with the largest number of publications in Chinese and English literatures are Ren Yuzhen and Ma Jin Yeul, respectively. The high frequency keywords in Chinese literatures are “fermentation”, “traditional Chinese medicine”, etc., while those in English literatures are “gut microbiota”, “antioxidant”, “traditional Chinese medicine”, etc. The clustering and burst analysis of Chinese and English keywords indicate that the research hotspots focus on fermentation mechanisms, strains, medicinal materials, process optimization, and applications.Conclusion Chinese literatures mainly focus on the fermentation processes, strains, medicinal materials, and applications of traditional Chinese medicine fermentation. In contrast, English literatures lay emphasis on fermentation mechanisms, pharmacological effects, drug synthesis, and purification. In - depth research on gut microbiota, metabolism, probiotics, and bioactive components represents the key development trend of TCM fermentation in the future.

G350;R282.15

江西省重点研发计划项目（20224BBG71023）；江西中医药大学首批校级科技创新团队项目（CXTD22008）；博士科研启动基金项目（2018BSZR001）；江西省大学生创新训练计划项目（S202410412122，S202410412123）