[关键词]
[摘要]
甘草Glycyrrhizae Radix et Rhizoma是一种常见的补益药，具有补脾益气、清热解毒和调和诸药等疗效，近年来其抗抑郁作用受到关注。通过检索近年来甘草抗抑郁相关文献，从甘草抗抑郁活性成分、抗抑郁机制以及复方应用等方面进行综述，表明甘草黄酮类、三萜类等成分具有抗抑郁作用，其主要抗抑郁机制涉及调节神经递质、抗氧化应激、抗炎以及调节“微生物-肠-脑轴”等。有助于进一步揭示甘草抗抑郁的分子机制，为甘草抗抑郁活性成分的开发和利用提供思路和参考。
[Key word]
[Abstract]
Gancao (Glycyrrhizae Radix et Rhizoma) is a widely used tonic in traditional Chinese medicine, which exerts the effects of nourishing the spleen and benefiting the qi, clearing heat and detoxifying, and harmonizing various medicines. Its antidepressant effects have gained increasing attention in recent years. In this study, we reviewed the active ingredients, the molecular mechanism and clinical application of this herb. The results showed that flavonoids and triterpenoids exhibit antidepressant effects. Their main antidepressant mechanisms involve the regulation of neurotransmitters, antioxidative stress, anti-inflammatory, and “microbiological-gut-brain axis”. This review further reveals the antidepressant mechanisms of active ingredients in Glycyrrhizae Radix et Rhizoma, which can provide suggestions for its utilization.
[中图分类号]
R285
[基金项目]
国家自然科学基金项目（82204613）；湖南省自然科学基金项目（2023JJ30465）；湖南省教育厅优秀青年项目（24B0363）；湖南中医药大学校级科研项目（2021XJJJ026，2024XJB001，Z2023XJYB22）；湖南中医药大学中药粉体与创新药物省部共建国家重点实验室培育基地开放基金项目（2022FTKFJJ08）；湖南中医药大学本科生科研创新基金（2023BKS151）
