动脉粥样硬化性心血管疾病（atherosclerosis cardiovascular disease，ASCVD）已逐渐成为导致中国人口疾病死亡的主要原因之一，大量研究表明中药在动脉粥样硬化的治疗中具有多靶点、效果显著、不良反应小等优势，且在该方面取得了一定进展，因此开发治疗和预防动脉粥样硬化（atherosclerotic，AS）的中药并阐明这些中药及其活性成分改善AS的作用机制具有重要意义。胆汁酸及其代谢可通过多种途径积极参与并有效促进AS的改善，为心血管疾病提供新的治疗靶点。通过从胆汁酸受体及肠道菌群影响方面综合阐述胆汁酸代谢对AS的影响，及中药及其活性成分在相关机制的具体应用研究进行综述。旨在进一步对AS的发病机制加深认识，为中药通过调节胆汁酸代谢发挥抗AS作用提供思路。

Atherosclerosis cardiovascular disease (ASCVD) has became one of the leading causes of death in China. Many studies indicate that traditional Chinese medicine (TCM) offers multi-target treatment for atherosclerosis, with significant effects and mild adverse reactions, and progress has been made in this regard. Thus, it’s vital to develop TCM for treating and preventing atherosclerotic (AS) and clarify the mechanisms of TCM and its active components in improving AS. Bile acid metabolism can actively participate in and promote AS improvement through various pathways, presenting new therapeutic targets for CVD. This article comprehensively discusses the impact of bile acid metabolism on AS from the perspectives of bile acid receptors and intestinal microbiota. It also reviews the research on the application of TCM and its active components in the related mechanisms. The aim is to deepen the understanding of AS pathogenesis and provide ideas for TCM to exert anti-AS effects by regulating bile acid metabolism.

R285

国家自然科学基金资助项目（81960730）