目的 基于文献计量学方法分析中药多糖免疫调节研究现状并预测未来的发展趋势，并通过专利分析得到中药多糖免疫调节成果转化情况。方法 分别从中国知网（CNKI）数据库、Web of Science （WOS）数据库核心集中收集文献，利用CiteSpace软件对文献进行可视化分析；分别从国家知识产权局（China National Intellectual Property Administration，CNIPA）数据库、世界知识产权组织（World Intellectual Property Organization，WIPO）数据库中收集相关专利，利用ItgInsight软件进行可视化分析。结果 中药多糖免疫调节领域年发文量整体呈先上升后稳定的趋势。期刊发文量International Journal of Biological Macromolecules以242篇居于英文期刊首位，《中草药》以23篇居于中文期刊首位。英文期刊发文量最多的作者为Wang Deyun（29篇），中文期刊为谷新利（16篇）。南昌大学和南京农业大学以19篇并列中文文献发文机构第1，南京农业大学以78篇居于英文文献发文机构榜首。中英文文献关键词显示，该领域的主要研究方向为中药多糖对免疫细胞的干预、中药多糖的免疫活性和抗肿瘤活性、中药多糖调节肠道菌群参与免疫调节等。中药多糖免疫调节相关专利主要集中于A61（医学）、A23（食品）、C08（有机高分子化合物）、C12（生物化学）和C07（有机化学）领域。结论 中药多糖免疫调节作用研究领域已初具规模，相关基础研究丰富，但是受相关理论与技术制约，该领域研究层次较为浅显，产业化开展也难成规模，需要相关专家团队攻克技术瓶颈，深挖中药多糖的免疫调节内在机制，注重产品开发和临床应用。

Objective Based on bibliometric methods with CiteSpace, the research analyzed the status of immune regulation by traditional Chinese medicine polysaccharides (TCMP), and predicted future development trends. The transformation of immunomodulatory results of TCMP was obtained by patent analysis. Methods The literature on the immune regulation of TCMP was collected from the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) database and visualized by CiteSpace software. Patents related to the immune regulation of TCMP were collected from the State Intellectual Property Office (CNIPA) and the World Intellectual Property Organization (WIPO) database and visualized by ItgInsight software. Results The annual number of papers published in the field of immune regulation of TCMP showed a trend of rising first and then stabilizing. The number of articles published in the International Journal of Biological Macromolecules ranked first with 242 in English journals, and Chinese Traditional and Herbal Drugs ranked first with 23 in Chinese journals. Wang, Deyun (29 articles) was the author with the largest number of articles published in English journals, while Gu Xinli (16 articles) had the highest publication count in Chinese. Nanchang University and Nanjing Agricultural University tied for first in Chinese literature with 19 articles, while Nanjing Agricultural University ranked first in English with 78 publications. Chinese and English keywords analysis show that the main research directions in this field are the intervention of TCMP on immune cells, the immune activity and anti-tumor activity of TCMP, and the regulation of intestinal flora involved in immune regulation by TCMP, etc. The patents related to the immune regulation of TCMP are mainly concentrated in the fields of A61 (medicine), A23 (food), C08 (organic polymer compounds), C12 (biochemistry) and C07 (organic chemistry). Conclusion The research field on the immunomodulatory effects of TCM polysaccharides has begun to take shapewith abundant basic studies. However, due to the difficulties in the extraction, separation and purification of TCMP and structural identification, the research level in this field is relatively shallow, and industrialization is difficult to achieve scale. However, the rise of immunosuppression and intestinal flora in recent years could lead to the immunomodulatory effects of TCMP. Relevant expert teams are required to overcome technical bottlenecks, explore the internal mechanism of immune regulation of TCMP, and pay attention to product development and clinical application.

G350；R285；R284

江苏省高校自然科学基金重大A类项目（24KJA360007）；中药学一流学科“引领计划”科学研究专项（ZYXYL2024-001）；中药学一流学科前沿探索性交叉科学研究项目（ZYXJC2024-010）；江苏省智慧中医药健康服务工程研究中心项目（ZHZYY202413）；中央本级重大增减支项目（2060302）；国家中医药管理局高水平中医药重点学科建设项目—中药资源化学（ZYYZDXK-2023083）