目的 研究石香薷Mosla chinensis全草的化学成分。方法 经正、反相硅胶柱色谱、高效液相色谱制备分离，并通过HR-MS、NMR、ECD等谱学数据鉴定化合物结构。结果 从石香薷超临界二氧化碳流体浸膏的95%乙醇提取物的乙腈萃取部位分离得到6个化合物，鉴定出1个半日花烷（labdane）二萜，1个γ-丁内酰胺取代的百里香酚衍生物，1个异香豆素，1个黄酮，1个木脂素，1个脂肪酸，分别为6S,7R,16-三羟基-半日花-8(17),12(E),14-三烯（1）、5-(4-羟基-5-异丙基-2-甲基苯基)-吡咯烷-2-酮（2）、(8S)-8,9-二氢-8-(1-羟基-1-甲基乙基)-6-甲氧基-2H-呋喃并[2,3-h]-5-苯并-γ-吡喃酮（3）、黄芩素-7-甲醚（4）、α-(9′Z,12′Z,15′Z)-十八碳三烯酸甘油酯（5）、丁香树脂酚（6）。结论 化合物1～3为新化合物，分别命名为香薷萜A（moslachinterpene A）、香薷内酰胺A（moslachinlactam A）以及异香薷素A（isomoslachinin A）；化合物5首次从本属植物中分离得到。

Objective To study the chemical constituents of the whole plants of Mosla chinensis.Methods Compounds were isolated and purified by normal and reversed column chromatography and high performance liquid chromatography. Their structures were identified on the basis of spectral data including MS, NMR and ECD. Results A total of six compounds including labdane diterpene, γ-butyrolactam and isocoumarin derivatives, were isolated from the acetonitrile extract of supercritical carbon dioxide extractum of M. chinensis. They were identified as 6S,7R,16-trihydroxy-labda-8(17),12(E),14-triene (1), 5-(4-hydroxy-5-isopropyl-2-methylphenyl)-pyrrolidin-2-one (2), (8S)-8,9-dihydro-8-(1-hydroxy-1-methylethyl)-6-methoxy-2H-furo[2,3-h]-5-benzopyran-1-one (3), negletein (4), α-(9′Z,12′Z,15′Z)-octadecatrienoic acid monoglyceride (5), and syringaresinol (6). Conclusion Compounds 1—3 are new compounds, named moslachinterpene A, moslachinlactam A, and isomoslachinin A. Compound 5 is isolated from the Mosla genus for the first time.

R284.1

湖北省重点研发计划项目（2024BCA002）；中南民族大学中央高校基本科研业务费专项资金（CZQ24023）；国家计划生育委员会计划生育科研项目（9906）