桑白皮是桑科植物桑Morus alba的干燥根皮，其化学成分主要包括Diels-Alder型加合物、黄酮、茋类、香豆素、生物碱、萜烯和酚酸等，具有降血压、降血糖、调血脂、镇咳、平喘、祛痰、利尿、抗炎、镇痛、抗病毒、抗肿瘤、抗氧化、护肝和美白等药理作用。通过基于桑白皮化学成分和药理作用的研究进展，从产地、炮制工艺、化学成分可测性、药效药性理论、网络药理学及入血成分等方面对桑白皮质量标志物（quality marker，Q-Marker）进行预测，初步预测甜桑皮苷A、桑皮苷C、桑根酮D、桑根酮C、桑辛素、桑黄酮G、桑辛素M、桑辛素D可作为桑白皮Q-Marker，为完善桑白皮量评价体系提供参考。

Sangbaipi (Mori Cortex), derived from the dried root bark of Morus alba (Moraceae family), contains diverse chemical constituents including Diels-Alder adducts, flavonoids, stilbenes, coumarins, alkaloids, terpenes, and phenolic acids. It exhibits comprehensive pharmacological properties encompassing antihypertensive, hypoglycemic, hypolipidemic, antitussive, anti-asthmatic, expectorant, diuretic, anti-inflammatory, analgesic, antiviral, antitumor, antioxidant, hepatoprotective, and skin-whitening effects. This review synthesizes recent advances in the phytochemistry and pharmacodynamics of Mori Cortex to conduct predictive analysis of its quality markers (Q-Markers) through multidimensional evaluation criteria: geographical origin, processing techniques, measurability of chemical constituents, pharmacodynamic and property theories, network pharmacology, and blood-absorbed components. Tentatively proposed Q-Markers candidates include sweet mulberroside A, mulberroside C, sanggenon D, sanggenon C, moracin, kuwanon G, moracin M, and moracin D. These findings provide a scientific foundation for optimizing the quality evaluation system of Mori Cortex, bridging phytochemical characterization with therapeutic efficacy validation in traditional medicine research.

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安徽省高校科研项目-重大项目（2024AH040159）；安徽省高校协同创新项目（GXXT-2023-073）；亳州职业技术学院第一批“医疗服务与保障能力提升补助”专项课题（YLFW1320）