白术Atractylodis Macrocephalae Rhizoma-白芍Paeoniae Radix Alba为临床常用药对，二药配伍后相使而行，善于调和肝脾。以白术-白芍为核心或组成部分的方剂，其功效在不同的方剂配伍情境下存在差异。白术-白芍富含多种化学成分，因炮制方法、药物配比、检测条件等因素不同，其主要成分白术内酯、芍药苷、芍药内酯苷等经配伍、炮制后含量也有所变化。白术-白芍治疗疾病机制聚焦于胃肠功能调节、抗炎、调节免疫及神经保护方面。通过对相关文献的检索与整理，主要从复方配伍、物质基础及作用机制方面对白术-白芍药对进行系统论述，为该药对的深入研究及开发应用提供思路和科学依据。

Baizhu (Atractylodis Macrocephalae Rhizoma)-Baishao (Paeoniae Radix Alba) is commonly used clinical drug pairs. After the two drugs are combined, they work together and are good at harmonizing the liver and spleen. The efficacy of prescriptions with Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba as the core or component varies in different prescription compatibility situations. Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba are rich in a variety of chemical components. Due to different processing methods, drug ratios, detection conditions and other factors, the content of its main components, such as atractylenolide, paeoniflorin, and paeoniflorin, also changes after compatibility and processing. The mechanism of Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba in treating diseases focuses on gastrointestinal function regulation, anti-inflammation, immune regulation and neuroprotection. This study systematically discusses Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba pair from the aspects of compound compatibility, material basis and mechanism of action through the retrieval and collation of relevant literature, in order to provide ideas and scientific basis for the in-depth research and development and application of this drug pair.

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国家自然科学基金面上项目（81573870）；国家中医药管理局第五批全国中医临床优秀人才研修项目（国中医药人教函 [2022] 239号）；第五批全国中医临床优秀人才研修项目（国中医药人教函[2022] 1号）；全国中医药创新骨干人才培养项目（国中医药人教函[2019] 128号）