肺纤维化是一种慢性间质性肺疾病的末期表现，预后极差，严重影响患者的生活质量。上皮-间充质转化（epithelial-mesenchymal transition，EMT）过程的激活作为肺纤维化的发病机制之一，在肺纤维化病理过程中具有重要作用。研究表明，中药单味药、活性成分及其复方制剂在改善纤维化症状和延缓疾病进程方面具有显著效果，其作用机制与直接或间接抑制EMT密切相关。因此，通过对中药抑制EMT干预肺纤维化进行综述，为临床肺纤维化的治疗提供参考。

Pulmonary fibrosis (PF) is a late-stage manifestation of chronic interstitial lung disease characterized by an extremely poor prognosis, significantly impacting the quality of life for patients. Activation of the epithelial-mesenchymal transition (EMT) process, as one of the pathogenic mechanisms of pulmonary fibrosis, plays an important role in the pathological process of pulmonary fibrosis. Studies have shown that single herbs, active ingredients and their compound preparations have significant effects in improving fibrosis symptoms and delaying the disease process. The mechanism of action is closely linked to the direct or indirect inhibition of EMT. This finding underscores the importance of inhibiting EMT as a crucial component of traditional Chinese medicine (TCM) in treatment of pulmonary fibrosis. Therefore, this article reviews the research on the role of TCM in inhibiting EMT in pulmonary fibrosis, aiming to provide a reference for the clinical treatment of this condition.

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国家自然科学基金重点项目（U21A20406）；安徽省科技重大专项（202303a07020007）