目的 探索清咳平喘颗粒治疗肺炎支原体肺炎患儿（风热闭肺证、痰热闭肺证）的临床有效性及安全性。方法 选取2023年2月—2024年2月在黑龙江中医药大学附属第一医院、宜兴中医院、商丘市第一人民医院、扬州市中医院、北京市房山区妇幼保健院、许昌市人民医院6个中心收治的230例患儿，采用区组随机分为对照组112例，治疗组118例。对照组采用西医基础治疗，治疗组在对照组治疗的基础上加服清咳平喘颗粒，比较两组临床疗效、临床痊愈时间、临床症状消失时间、体征症状积分、炎症指标、肺功能、肺炎吸收情况及住院天数。结果 治疗组临床总有效率（98.31%）显著高于对照组（92.86%）（P＜0.05），两组均可显著改善患儿症状、体征积分，降低炎症因子水平，改善患儿肺功能（P＜0.05），其中治疗组的治疗作用均显著强于对照组（P＜0.05）。与对照组相比，治疗组可显著缩短患儿临床痊愈时间，促进患儿发热、咳嗽、咯痰、气喘、肺部听诊等临床症状消失，提高患儿肺炎吸收评分，缩短住院天数（P＜0.05）。结论 清咳平喘颗粒联合西医常规治疗能够显著提高临床治疗的有效率，促进患儿临床症状、体征改善，提高患儿肺功能水平，降低炎症反应，促进肺炎吸收，缩短住院时间，促进疾病转归，且安全性良好，值得临床推广与应用。

Objective To explore the clinical efficacy and safety of Qingke Pingchuan Granules (清咳平喘颗粒) in the treatment of children with Mycoplasma pneumoniae pneumonia (wind heat closed lung syndrome, phlegm heat closed lung syndrom). Methods A total of 230 children admitted to the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Yixing Hospital of Traditional Chinese Medicine, Shangqiu First People’s Hospital of Traditional Chinese Medicine, Yangzhou Hospital of Traditional Chinese Medicine, Beijing Fangshan Maternal and Child Health Hospital and Xuchang People’s Hospital from February 2023 to February 2024 were selected and randomly divided into the control group (112 cases) and the treatment group (118 cases). The control group received basic Western medicine treatment, while the treatment group was given Qingke Pingchuan Granules in addition to the control group treatment. The clinical efficacy, clinical recovery time, clinical symptom disappearance time, physical sign symptom score, inflammatory indicators, lung function, pneumonia absorption, and hospitalization days were compared between the two groups. Results The clinical effective rate of the treatment group (98.31%) was significantly higher than that of the control group (92.86%) (P < 0.05). Both groups significantly improved the child patient’s symptom and sign scores, reduced inflammatory factor levels, and improved lung function (P < 0.05). The therapeutic effect of the treatment group was significantly stronger than that of the control group (P < 0.05). In addition, compared with the control group, the treatment group can significantly shorten the clinical recovery time of the children, promote the disappearance of clinical symptoms such as fever, cough, sputum, asthma, and lung auscultation, improve the pneumonia absorption score of the children, and shorten the length of hospital stay (P < 0.05). Conclusion The combination of Qingke Pingchuan Granules and conventional Western medicine treatment can significantly improve the effectiveness of clinical treatment, promote the improvement of clinical symptoms and signs in pediatric patients, improve lung function levels, reduce inflammatory reactions, promote pneumonia absorption, shorten hospitalization time, promote recovery, and have good safety. It is worthy of promotion and application in clinical practice.

R285.64