癌症是威胁人类生命健康的主要公共卫生问题之一，传统的化疗手段药物缺乏选择，开发来自于中草药中的天然抗肿瘤成分正受到越来越多的关注。甘草是最常用的中药材之一，甘草中的黄酮类成分作为其主要活性成分，在现代研究中被报道具有广泛的抗肿瘤活性。为进一步明确甘草黄酮类成分的抗肿瘤活性，该文对近十年关于甘草黄酮类成分抗肿瘤研究进行综述。通过检索PubMed、Web of Science、中国知网等数据库，对甘草黄酮类成分中具有抗肿瘤活性的主要成分及其抗肿瘤机制进行了总结，同时综述了甘草黄酮类成分不同的纳米递送给药在抗肿瘤领域的应用，并对甘草黄酮类成分的毒理机制研究进行了梳理。结果发现甘草黄酮类成分在多种类型癌症中具有抗癌活性，合适的纳米给药方式能增强甘草黄酮类成分的抗肿瘤活性，关于甘草黄酮类成分的毒理学研究还较少。总的来说，甘草中的黄酮类成分是十分具有开发潜力的抗肿瘤天然产物，对甘草黄酮类成分的纳米递送及毒理研究可能未来研究热点，值得进一步开发研究。

Cancer represents a significant public health challenge that jeopardizes human life and well-being. Traditional chemotherapy options are limited, the development of natural anti-tumor agents derived from Chinese herbal medicine is receiving more and more attention. Licorice, one of the most frequently utilized medicinal materials in Chinese tradition, contains flavonoids that have been reported to exhibit considerable anti-tumor activity according to contemporary research. To further elucidate the anti-tumor properties of licorice flavonoids, the relevant studies conducted over the past decade are reviewed in this article. By examining databases such as PubMed, Web of Science, and China National Knowledge Infrastructure, the primary components of licorice flavonoids that possess anti-tumor activity and their corresponding mechanisms of action are summarized. Additionally, the application of nano-delivery systems for various licorice flavonoid components in drug delivery, as well as the research surrounding the toxicological mechanisms associated with these flavonoids are explored. The findings indicate that licorice flavonoids exhibit anti-cancer properties across multiple cancer types, and that appropriate nano-delivery methods can enhance their anti-tumor efficacy. However, there is a paucity of toxicological studies on licorice flavonoids. Overall, the flavonoids present in licorice are promising natural anti-tumor agents that merit further development and investigation.

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国家自然科学基金项目（82074397）;四川省科技创新苗子工程培育项目（MZGC20230053）;成都体育学院卓越科研计划项目（ZYRC2406）