山茱萸Cornus officinalis作为中国传统重要中药品种之一，资源丰富，其成分、药理作用多样，具有极大药用价值。目前从山茱萸中分离鉴定出多种化学物质，包括环烯醚萜类及其苷、三萜类、有机酸类、黄酮类、多糖等；药理作用主要有抗肿瘤、降血糖、保护神经元、抗氧化和抗炎等。通过检索近20年国内外相关文献，对山茱萸的主要化学成分、药理作用进行综述，为探究山茱萸的现代临床作用的机制方面提供新的思路和方向。

Cornus officinalis, as one of the important traditional Chinese medicinal varieties in China, is rich in resources, with a variety of constituents, pharmacological effects and great medicinal value. At present, a variety of chemical substances have been isolated and identified from C. officinalis, including iridoid terpenoids and their glycosides, triterpenoids, organic acids, flavonoids, polysaccharides, etc.; and the pharmacological effects mainly include antitumor, hypoglycemia, neuron protection, antioxidant and anti-inflammatory. In this manuscript, the main chemical constituents and pharmacological effects of C. officinalis are reviewed by searching the relevant literature at home and abroad in the past 20 years, with a view to providing new ideas and directions for the study of C. officinalis’ mechanism in modern clinical practice.

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国家自然科学基金青年科学基金项目（82104394）;浙江省基础公益研究项目（LY23H280008）