目的 研究香榧Torreya grandis的化学成分。方法 采用各种类型柱色谱及半制备液相色谱进行分离纯化，经波谱数据鉴定化合物结构，MTT法检测化合物的肿瘤细胞毒活性。结果 从香榧树皮中分离鉴定了4个木脂素类化合物，分别为 (8R,7'S,8'R)-4,4'-二羟基-3,3',5',7'-四甲氧基木脂烷-9,9'-内酯（1）、桧脂素（2）、扁柏脂素（3）和traxillagenin（4）。结论 化合物1为新的木脂素类化合物，命名为香榧木脂素A；其余化合物均为首次从香榧中分离得到。化合物2～4在20μmol/L浓度下对HCT-116和AsPC-1癌细胞有一定的抑制作用。

Objective To elucidate the chemical constituents of Torreya grandis var. merrillii. Methods The compounds were isolated and purified using various methods, including column chromatography and semi-preparative liquid chromatography. The structures of the isolated compounds were identified through spectral data analysis. The cytotoxic activities of these compounds were assessed using the MTT assay. Results A total of four lignan compounds were isolated, and their structures were identified as follows: (8R,7'S,8'R)-4,4'-dihydroxy-3,3',5',7'-tetramethoxy-lignane-9,9'-lactone (1), savinin (2), hinokinin (3), and traxillagenin (4). Conclusion Compound 1 is a new compound named torregrandlignan A, while the remaining compounds were isolated for the first time from T. grandis var. merrillii. Compounds 2—4 exhibited moderated cytotoxic activity against HCT-116 and AsPC-1 cells.

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国家自然科学基金资助项目（31560102）;中央高校基本科研业务费专项基金（ZYN2024008）;科技基础资源调查专项资助（2022FY102000）——民族医药疫病文献辑录及其防治疫病的经验研究（2022FY102004）