黑色素瘤是高度易于转移的肿瘤之一，其主要的转移器官有肺、淋巴结、脑等。黑色素瘤的转移与上皮-间质转化（epithelial-mesenchymal transition，EMT）、代谢重编程及免疫微环境密切相关。EMT使黑色素瘤细胞变得更具侵袭性，同时伴随代谢重编程，为细胞提供能量支持，助长免疫逃逸，促使肿瘤发展和转移。中药可通过抑制EMT过程、调控代谢重编程及重塑免疫微环境发挥抗黑色素瘤转移的作用。通过系统综述黑色素瘤的转移过程及中药抗黑色素瘤转移的研究，为中药抗黑色素瘤研究提供科学依据和理论基础。

Melanoma is one of the highly metastatic tumors. The main metastatic organs are lung, lymph nodes, brain and so on. The metastasis of melanoma is closely related to epithelial-mesenchymal transition (EMT), metabolic reprogramming and immune microenvironment. EMT makes melanoma cells more invasive, accompanied by metabolic reprogramming, providing energy support for cells, promoting immune escape, and promoting tumor development and metastasis. Traditional Chinese medicine plays a role in anti-melanoma metastasis by inhibiting EMT process, regulating metabolic reprogramming and remodeling immune microenvironment. This paper systematically reviews the metastasis process of melanoma and the research progress of traditional Chinese medicine against melanoma metastasis, and provides scientific basis and theoretical basis for the study of traditional Chinese medicine against melanoma.

R285

山东中医药大学科学研究基金资助项目（KYZK2024M21）;国家自然科学基金资助项目（82204656）