植物来源的细胞外囊泡（plant-derived extracellular vesicles，PDEVs）是植物细胞释放的纳米级囊泡，内含蛋白质、脂质、核酸等生物活性物质，不仅参与机体生理病理过程的调控，如跨界通讯、细胞增殖分化、免疫调节和炎症反应等，还可克服生物屏障作为药物载体靶向病变部位，对疾病的转归起到关键作用。随着对PDEVs研究的深入，其在肠肝疾病防治的应用潜力逐渐显现。然而关于PDEVs如何通过肠-肝轴发挥治疗作用的潜在机制尚未明确，鉴于PDEVs具备良好的自然靶向性、生物相容性等突出优势，从肠-肝轴的角度切入，在肠道、肝脏及二者之间相互调节和通信层面上对PDEVs防治肠肝疾病的分子作用机制进行总结探讨，为PDEVs治疗肠肝疾病的研究提供新的思路与方法。

Plant-derived extracellular vesicles (PDEVs) are nano-sized vesicles released by plant cells, which contain protein, lipids, nucleic acids and other bioactive substances. PDEVs not only participate in the regulation of physiological and pathological processes of the body, such as cross-border communication, cell proliferation and differentiation, immune regulation, and inflammatory reaction but also can overcome the biological barrier as a drug carrier to target the lesion and play a key role in prognosis of the disease. With the in-depth study of PDEVs, their application potential in prevention and treatment of intestinal and liver diseases has gradually emerged. However, the potential mechanism of how PDEVs can play a therapeutic role through the intestinal-hepatic axis is not clear. Given PDEVs’ outstanding advantages such as good natural targeting and biocompatibility, in this paper, the molecular mechanism of PDEVs in preventing and treating intestinal-hepatic disease is summarized and discussed from perspective of intestinal-hepatic axis, to provide new ideas and methods for research of PDEVs in treating intestinal-hepatic disease.

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国家自然科学基金资助项目（82474217）;济南市“新高校20条”资助项目（202333018）